The purpose of this study is to assess the potential of novel molecular polarimetric imaging techniques utilizing multi-index of refraction targets, i.e. composite targets made from optically different media, immersed into biological fluids doped with optically active molecules and enzymes. The outcome of this study indicates that the application of Stokes parameter detection principles with concominant administration of fluids containing suitable optically active molecular contrast agents and high index of refraction molecules could enhance the detection and imaging process of internal structures by providing enhanced penetration depth, high contrast and high depolarized scatter rejection.