For simulation purposes related to Spacecraft Operations, ESA has developed a generic simulation tool set called SIMULUS. This toolset comply with the ESA Simulation Model Portability standard, hence ensuring that the environment remain generic hence reusable not only across ESA missions, but as well for other none space related domains. As part of the ESA study “Linux & Multi Core Processor Technology for Simulators”, several concepts concerning performance optimization of SIMULUS based operational simulators were introduced. Starting from the possibility to explore parallelism and distributed execution of computational loads and continuing with the profiling, analysis and focused optimization of specific simulation models our efforts and ideas converged to a generic Performance Optimization Framework (POF). The present paper summarizes the way the idea of a Performance Optimization Framework can be applied in future operational simulators or other simulations using the SIMULUS software.