Timely identification and localization of infectious and inflammatory process are of critical importance in the treatment of patients presenting with suspicion of infection and inflammation. Whilst other radiological techniques (CT, MRI, US) are used for the localization of infectious foci, they rely merely on anatomical changes. Therefore, there has to be a reasonable elapse of time before the infection is diagnosed. In contrast, scintigraphic detection of infection and inflammation is a non-invasive method of whole-body scanning based on functional tissue changes. Several radiopharmaceuticals are currently employed for the scintigraphic imaging of infection and inflammation. Especially in the case of bone and joint infection there is a choice among a number of radiopharmaceuticals available for the localization of the lesion. In this study two radiopharmaceuticals are compared on dosimetric and diagnostic bases. The radiopharmaceuticals under evaluation are Ga67- citrate, and Tc99m- Anti-Granulocyte, Ga67-citrate being a traditional agent utilized for the detection of inflammation and Tc99mAnti-Granulocyte being a relatively new radiopharmaceutical. Both agents were used for the detection of a suspected infectious lesion in the lower limbs.