Introduction: Injuries are a major cause of morbidity and mortality either in developing or in developed countries. The identification of injuries' characteristics and trends may be a useful tool for designing public health interventions and for minimizing the costs in the community. Objective: Aim of the present study was to assess the trends and the characteristics of injuries recorded during the five-year period 2000-2004 in the Municipality of Galatsi, one of the most inhabited areas in Athens. Materials and Methods: For the purpose of this retrospective study, the Registries of the main Insurance Institution (I.K.A.) of the citizens of Galatsi Municipality were used. All injuries were recorded according to their external cause and nature of accident for the five year period 2000-2004. The time, place and outcomes (hospitalization, sick leave) of these accidents were recorded. Several demographic characteristics of the study population were also gathered. Results: In total, 1512 accidents were recorded for the five year period 2000-2004. An overtime decreasing trend in the accidents' frequency was observed. Most of the accidents occurred during June (9.6%), May (9.5%) and September (9.3%), whereas the month with the lowest accidents' frequency was August (6.2%). For the five-year period, 74.01% of the accidents occurred to males, whereas a clearly distribution by age was observed, with the age group 20-39 years old being the most affected (67.8%). Accidental falls presented the highest rates (59.3%), whereas the majority of the accidents were home and leisure accidents (33.0%). The major mean of choice for transportation to the respective health services is the car (56.5%) and only a small proportion of the affected population (15.1%) is being transported by the EKAB, the official National Center for Immediate Assistance. Conclusions: It is encouraging that for the five year period 2000-2004 an overtime decrease in accidents' frequency was observed. This finding is in accordance with the results of various studies concerning the unintentional fatal injuries in other European countries. A distribution by gender was recorded, with males presenting higher injuries' rates compared to females. This is consistent to the pattern observed worldwide and it is established the males are at greater risk for injuries since they adopt higher risk behaviors. As for other European countries, accidental falls presented the higher frequencies, whereas home and leisure accidents represented the majority of accidents occurring in our population. An interesting finding of the present study was the choice of mean of transportation to the health services. This needs further investigation and several measures should be consider in order to enhance the response and preparedness of the EKAB and consequently to reduce the mortality and the devastating costs of injuries in the community.