YVO4:Eu is a phosphor material emitting red light (621 nm) and providing excellent spectral compatibility with red sensitive optical detectors. However, it has never been used in medical X-ray imaging. In this study the imaging performance of six laboratory prepared YVO4:Eu test screens with coating weights from 30 to 140 mg/cm2 was examined by evaluating the modulation transfer function (MTF), the X-ray luminescence efficiency (XLE), and the detective quantum efficiency (DQE). DQE was evaluated by employing a method based on XLE and emission spectra measurements. The 30 mg/cm2 screen had a significantly higher MTF than thicker screens while its zero frequency DQE peak value was 0.27 at 30 kVp. Results obtained indicate that YVO4:Eu may be of value for use in X-ray imaging detectors.