Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Παπασωτηρίου, Ιωάννης	el
dc.contributor.author	Βουνάτσου, Μαρία	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Τσακίρης, Στυλιανός	el
dc.date.accessioned	2015-05-08T20:16:11Z
dc.date.available	2015-05-08T20:16:11Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/10002
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/15292337?dopt=AbstractPlus	en
dc.subject	φαινυλκετονουρία
dc.subject	ελεγχόμενη δίαιτα
dc.subject	φαινυλαλανίνη
dc.subject	τυροσίνη
dc.subject	αδρεναλίνη
dc.subject	ντοπαμίνη
dc.subject	συγκεντρώσεις των κατεχολαμινών
dc.subject	Phenylketonuria
dc.subject	diet-controlled
dc.subject	phenylalanine
dc.subject	Tyrosine
dc.subject	Adrenaline
dc.subject	Dopamine
dc.subject	catecholamine concentrations
dc.title	Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls	en
heal.type	journalArticle
heal.secondaryTitle	evidence for catecholamine-mediated ghrelin regulation	en
heal.classification	Κλινική βιοχημεία
heal.classification	Ενδοκρινολογία
heal.classification	Clinical biochemistry
heal.classification	Endocrinology
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Ενδοκρινολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2002006108
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85100698
heal.keywordURI	http://lod.nal.usda.gov/7802
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85139195
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85001007
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85039075
heal.contributorName	Χρούσος, Γεώργιος Π.	el
heal.identifier.secondary	DOI: http://dx.doi.org/10.1210/jc.2004-0311
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2004-08
heal.bibliographicCitation	Schulpis, K.H., Papassotiriou, I., Vounatsou, M., Karikas, G.A., Tsakiris, S. et al. (2004) Morning preprandial plasma ghrelin and catecholamine concentrations in patients with phenylketonuria and normal controls: evidence for catecholamine-mediated ghrelin regulation. The Journal of Clinical Endocrinology & Metabolism. [Online] 89 (8). pp.3983-3987. Available from: http://www.ncbi.nlm.nih.gov [Accessed 08/05/2015]	en
heal.abstract	Patients with phenylketonuria (PKU) have a diet-controlled deficiency in the conversion of phenylalanine (Phe) to tyrosine (Tyr), leading to decreased production of noradrenaline, adrenaline, and dopamine. Poor diet control results in high plasma Phe and low plasma Tyr and catecholamine concentrations. Ghrelin, a recently described gastrointestinal hormone that is elevated in the fasting state and low in the fed state, is considered a major appetite-stimulating hormone, possibly involved in the generation of obesity and insulin resistance. We evaluated morning preprandial plasma ghrelin levels in 14 diet-controlled and 15 poorly controlled PKU patients and 20 age- and body mass index (BMI)-matched healthy children (controls) and correlated its concentrations with those of Phe and catecholamines as well as with their BMI and 24-h nutrient intake. Plasma ghrelin levels were measured by RIA, plasma catecholamine concentrations were determined by HPLC with electrochemical detection, and Phe and Tyr levels were measured in an amino acid analyzer. The ghrelin concentration (744 +/- 25 ng/liter) in diet-controlled patients did not differ from that in controls (802 +/- 26 ng/liter; P > 0.05). On the contrary, the ghrelin concentration was significantly reduced in poorly controlled patients (353 +/- 23 ng/liter; P < 0.0001). Ghrelin correlated negatively with Phe in all three groups, whereas it correlated positively with catecholamine levels and energy intake and negatively with BMI only in diet-controlled patients and controls. We conclude that ghrelin secretion may receive positive direct or indirect input from catecholamines. The absence of a correlation between ghrelin and catecholamines, energy intake, or BMI in PKU patients on an inadequate diet may be due to dysregulation of their neuroendocrine system and might be affected by high Phe levels in the stomach and/or central nervous system.	en
heal.journalName	The Journal of Clinical Endocrinology & Metabolism	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true