The association of serum lipids, lipoproteins and apolipoproteins with selected trace elements and minerals in phenylketonuric patients on diet

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Καρακωνσταντάκης, Θεόδωρος	el
dc.contributor.author	Μπαρτζελιώτου, Αναστασία	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Παπασωτηρίου, Ιωάννης	el
dc.date.accessioned	2015-05-08T21:07:39Z
dc.date.available	2015-05-08T21:07:39Z
dc.date.issued	2015-05-09
dc.identifier.uri	http://hdl.handle.net/11400/10010
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/15158304?dopt=AbstractPlus	en
dc.subject	φαινυλκετονουρία
dc.subject	λιποπρωτεΐνες
dc.subject	Ιχνοστοιχεία
dc.subject	Ορυκτά
dc.subject	Phenylketonuria
dc.subject	Lipoproteins
dc.subject	Trace elements
dc.subject	Minerals in nutrition
dc.title	The association of serum lipids, lipoproteins and apolipoproteins with selected trace elements and minerals in phenylketonuric patients on diet	en
heal.type	journalArticle
heal.classification	Κλινική βιοχημεία
heal.classification	Διατροφή
heal.classification	Clinical biochemistry
heal.classification	Nutrition
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Διατροφή
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85093451
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85100698
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85077309
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85136387
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85085598
heal.identifier.secondary	DOI: 10.1016/j.clnu.2003.09.006
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2004-06
heal.bibliographicCitation	Schulpis, K.H., Karakonstantakis, T., Bartzeliotou, A., Karikas, G.A. and Papassotiriou, (2004) The association of serum lipids, lipoproteins and apolipoproteins with selected trace elements and minerals in phenylketonuric patients on diet. Clinical Nutrition. [Online] 23 (3). pp.401-407. Available from: http://www.ncbi.nlm.nih.gov [Accessed 08/05/2015]	en
heal.abstract	Objective: Classical phenylketonuria (PKU) is an inborn error of metabolism characterized by high Phenylalanine (Phe) levels in blood and treated with a special low Phe diet which can be defined as “nonatherogenic”. Since coronary heart disease (CHD) was reported to be a disease of zinc and copper imbalance, we aimed indirectly to evaluate the effect of the special diet on the size of LDL particles and to investigate whether some minerals and trace elements are involved in their lipoprotein metabolism. Methods: Eighty-six (N=86) PKU patients were divided into two groups. Group A (N=44) on a strict diet and group B (N=42) who did not adhere to their treatment. Healthy children (N=98) were the controls. Serum total cholesterol (t-Chol), triacylglycerol, High-density lipoprotein (HDL) and t-Chol in very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) were measured with enzymatic methods, whereas Apolipoprotein AI (Apo AI), Apolipoprotein AII (Apo AII) and Apolipoprotein B (Apo B) were determined by nephelometric techniques. LDL/Apo B positively correlated with LDL size. Magnesium (Mg), calcium (Ca), copper (Cu) and zinc (Zn) measurements were performed by atomic absorption spectrometry. Results: t-Chol, LDL, VLDL, Apo B, the ratio t-Chol/HDL, Apo AI/Apo B and LDL/Apo B as well as copper levels and the ratio Zn/Cu in group A statistically significantly differed as compared to those of group B and Controls. Positive correlations were found between Mg and HDL and Apo AI in all the groups whereas the mineral correlated with t-Chol, Apo B and the ratio LDL/Apo B only in the group A of patients. Copper negatively correlated with triacylglycerol, LDL, and Apo B and positively with t-Chol in group A. Zinc showed negative relationships in HDL and Apo A in all the studied groups. The ratio Zn/Cu negatively correlated with triacylglycerol and LDL in all the groups and positively with the ratios Apo AI/Apo B and LDL/Apo B in group A. Conclusion: Some of the minerals and trace elements were correlated with the lipids and lipoproteins and were also involved in the size of LDL particles in PKU patients on strict diet. Larger and less atherogenic LDL particles were associated with a high Zn/Cu ratio.	en
heal.publisher	Elsevier	en
heal.journalName	Clinical Nutrition	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true