Effect of diet on plasma total antioxidant status in phenylketonuric patients

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Τσακίρης, Στυλιανός	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Μούκας, Μ.	el
dc.contributor.author	Μπεχράκης, Παναγιώτης	el
dc.date.accessioned	2015-05-08T22:21:47Z
dc.date.available	2015-05-08T22:21:47Z
dc.date.issued	2015-05-09
dc.identifier.uri	http://hdl.handle.net/11400/10016
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.nature.com/ejcn/journal/v57/n2/full/1601529a.html	en
dc.subject	αντιοξειδωτική κατάσταση
dc.subject	φαινυλκετονουρία
dc.subject	καροτένιο
dc.subject	τοκοφερόλη
dc.subject	βιταμίνη C
dc.subject	χορτοφαγική διατροφή
dc.subject	antioxidant status
dc.subject	Phenylketonuria
dc.subject	beta-carotene
dc.subject	alpha-tocopherol
dc.subject	Vitamin C deficiency
dc.subject	vegetarian diet
dc.title	Effect of diet on plasma total antioxidant status in phenylketonuric patients	en
heal.type	journalArticle
heal.classification	Διατροφή
heal.classification	Φαρμακευτική
heal.classification	Nutrition
heal.classification	Pharmacy
heal.classificationURI	N/A-Διατροφή
heal.classificationURI	N/A-Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85093451
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85100698
heal.keywordURI	http://lod.nal.usda.gov/16812
heal.keywordURI	http://lod.nal.usda.gov/6949
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143980
heal.keywordURI	http://lod.nal.usda.gov/316
heal.identifier.secondary	DOI: 10.1038/sj.ejcn.1601529
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2003-02
heal.bibliographicCitation	Schulpis, K.H., Tsakiris, S., Karikas, G.A., Moukas, M. and Behrakis, P. (2003) Effect of diet on plasma total antioxidant status in phenylketonuric patients. European Journal of Clinical Nutrition. [Online] 57 (2). pp.383-387. Available from: http://www.nature.com [Accessed 08/05/2015]	en
heal.abstract	Background: Phenylketonuria (PKU), an inborn error of phenylalanine (Phe) metabolism, is treated with a low Phe lifelong diet, which is a vegetarian and contains many antioxidants. Aim: The aim of this study was to evaluate the effect of diet on plasma total antioxidant status in our PKU patients. Methods, Results: Twenty-two PKU patients on strict diet (group A), 24 PKU patients who did not accurately follow their dietary control (group B) and 40 healthy children (controls) of comparable age took part in this study. Nutrients, as well as blood levels of lipids, vitamin C, beta-carotene and alpha-tocopherol were evaluated in all groups. Vitamin C intake and its blood levels did not differ between the groups. However, the intake of beta-carotene, alpha-tocopherol (2211plusminus116, 14plusminus1.0 mg/24 h) and their blood levels (0.7plusminus0.09, 34plusminus0.9 micromol/l) in group A were statistically significantly higher (P<0.001) as compared with those of group B (1352plusminus118, 10plusminus1.0 mg/24 h and 0.49plusminus0.08, 22plusminus0.6 micromol/l) and controls (1290plusminus120, 9.0plusminus0.9 mg/24 h and 0.40plusminus0.09, 24plusminus1.6 micromol/l). Lipid intakes and their blood levels were lower in patients on the strict diet. Plasma total antioxidant status was higher in the same group of patients (group A). Additionally, positive correlations were found between the antioxidant vitamin blood levels and the plasma total antioxidant status in the groups, especially in the group A. PKU patients of group A showed significantly higher antioxidant status (1.6plusminus0.2 mmol/l) as compared with those of group B (1.0plusminus0.19 mmol/l; P<0.001) and controls (1.01plusminus0.2 mmol/l). Conclusions: The high plasma antioxidant status in patients with PKU, especially in those with a good compliance with their diet, is possibly due to the amounts of antioxidants which are present in their special low Phe vegetarian diet.	en
heal.journalName	European Journal of Clinical Nutrition	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true