Homocysteine and other vascular risk factors in patients with phenylketonuria on a diet

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Παπακωνσταντίνου, Ευάγγελος Δ.	el
dc.date.accessioned	2015-05-09T17:30:18Z
dc.date.issued	2015-05-09
dc.identifier.uri	http://hdl.handle.net/11400/10030
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/12222713?dopt=AbstractPlus	en
dc.subject	ενδοθηλίνη
dc.subject	φολικό οξύ
dc.subject	ομοκυστεΐνη
dc.subject	λιπίδια
dc.subject	φαινυλκετονουρία
dc.subject	βιταμίνη Β6
dc.subject	βιταμίνη Β12
dc.subject	Endothelin
dc.subject	Folic acid
dc.subject	Homocysteine
dc.subject	Lipids in nutrition
dc.subject	Phenylketonuria
dc.subject	Vitamin B6
dc.subject	Vitamin B12
dc.title	Homocysteine and other vascular risk factors in patients with phenylketonuria on a diet	en
heal.type	journalArticle
heal.classification	Κλινική βιοχημεία
heal.classification	Φαρμακευτική
heal.classification	Clinical biochemistry
heal.classification	Pharmacy
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143995
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh96011736
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85077300
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85100698
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143967
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143970
heal.identifier.secondary	DOI: 10.1111/j.1651-2227.2002.tb02853.x
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2002-08
heal.bibliographicCitation	Schulpis, K.H., Karikas, G.A. and Papakonstantinou, E. (2002) Homocysteine and other vascular risk factors in patients with phenylketonuria on a diet. Acta Paediatrica. [Online] 91 (8). pp.905-909. Available from: http://www.ncbi.nlm.nih.gov [Accessed 09/05/2015]	en
heal.abstract	The aim of this study was to investigate the known risk factors, such as lipids, homocysteine and endothelin, for the development of coronary artery disease (CAD) in phenylketonuria (PKU) patients, depending on their diet. The PKU patients (n= 74) were divided into two groups. Group A (n= 34; mean age 6.78 ± 1.5 y) adhered strictly to a diet and group B (n= 40; mean age 8.0 ± 3.2 y) did not comply with the diet. The control group comprised 50 healthy non-PKU children. All groups were evaluated for blood levels of homocysteine and vitamin B6 by high-performance liquid chromatography, vitamin B12 and folate in serum by a radioassay, lipids by a routine method, and lipoprotein(a) and endothelin-1 with an immunoassay. Homocysteine levels (28.65 ± 3.3 μmol 1-1) were increased in group A compared with group B (6.86 ± 1.6 μmol 1-1) and the controls (6.9 ± 2.0 μmol 1-1) (p > 0.001). Vitamin B6 (10.7 ± 10.9 nmol 1-1), vitamin B12 (98.5 ± 22.3 pmol 1-1), folate (2.35 ± 1.3 nmol 1-1) and lipids were decreased in group A. The other vascular risk factors, which were not dependent on diet [lipoprotein(a) and endothelin-1], did not differ among the three groups. Conclusion: PKU patients on a strict diet had low vitamin B6, vitamin B12 and folate levels resulting in moderate hyperhomocysteinaemia. The evaluation of these vitamins at short intervals and their supplementation could be an early measure in the prevention of CAD.	en
heal.journalName	Acta Paediatrica	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false