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dc.contributor.author Σούλπη, Κλεοπάτρα en
dc.contributor.author Τζαμουράνη, Ιωάννα el
dc.contributor.author Καρίκας, Γεώργιος-Αλβέρτος el
dc.contributor.author Μιχελακάκη, Ελένη el
dc.contributor.author Τσακίρης, Στυλιανός el
dc.date.accessioned 2015-05-09T17:49:19Z
dc.date.available 2015-05-09T17:49:19Z
dc.date.issued 2015-05-09
dc.identifier.uri http://hdl.handle.net/11400/10033
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://www.ncbi.nlm.nih.gov/pubmed/12135689?dopt=AbstractPlus en
dc.subject Βιογενείς αμίνες
dc.subject επίπεδα της φαινυλαλανίνης στο αίμα
dc.subject φαινυλκετονουρία
dc.subject αμινοξέα
dc.subject Μεμβράνες ερυθροκυττάρων
dc.subject Biogenic amines
dc.subject Phenylalanine blood levels
dc.subject Phenylketonuria
dc.subject Amino acids
dc.subject Erythrocyte membranes
dc.title In vivo effects of high phenylalanine blood levels on Na+,K+-ATPase, Mg2+-ATPase activities and biogenic amine concentrations in phenylketonuria en
heal.type journalArticle
heal.classification Κλινική βιοχημεία
heal.classification Διατροφή
heal.classification Clinical biochemistry
heal.classification Nutrition
heal.classificationURI **N/A**-Κλινική βιοχημεία
heal.classificationURI **N/A**-Διατροφή
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85093451
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85014143
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85100698
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85004486
heal.keywordURI http://id.loc.gov/authorities/subjects/sh89006625
heal.identifier.secondary DOI: 10.1016/S0009-9120(02)00311-9
heal.language en
heal.access campus
heal.recordProvider Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων el
heal.publicationDate 2002-06
heal.bibliographicCitation Schulpis, K.H., Tjamouranis, J., Karikas, G.A., Michelakakis, H. and Tsakiris, S. (2002) In vivo effects of high phenylalanine blood levels on Na+,K+-ATPase, Mg2+-ATPase activities and biogenic amine concentrations in phenylketonuria. Clinical Biochemistry. [Online] 35 (4). pp.281-285. Available from: http://www.ncbi.nlm.nih.gov [Accessed 09/05/2015] en
heal.abstract Objective: To evaluate the activities of Na+,K+-ATPase and Mg2+-ATPase in erythrocyte membranes from phenylketonuric (PKU) patients and to correlate the enzyme activities with their blood phenylalanine (Phe) levels, biogenic amines as well as with their precursors tyrosine (Tyr) and tryptophan (Try). Design and methods: Twenty three PKU patients were divided into group A (n = 12) on a stricted diet (Phe 1.57 ± 0.52 mg/dL or 0.10 ± 0.03 mM) and group B (n = 11) on a “loose” diet (Phe 24.45 ± 1.50 mg/dL or 1.72 ± 0.09 mM). The enzyme activities were measured spectrophotometrically, the amino acids with an automatic amino analyser and the biogenic amines with HPLC methods. Results: In group B, plasma amino acids (Tyr, Try), their biogenic amines [adrenaline (A), noradrenaline (NA), dopamine (DA) and serotonin (5HT)], (Na+,K+)-ATPase and Mg2+-ATPase activities were found remarkably decreased (p < 0.001). Conclusions: High Phe and/or low NA, DA, 5HT plasma levels may indirectly inhibit the erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase in PKU patients. The observed enzyme inhibitions could be a very informative peripheral marker as regards the neurotoxic Phe brain effects. en
heal.publisher Elsevier en
heal.journalName Clinical Biochemistry en
heal.journalType peer-reviewed
heal.fullTextAvailability true


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες