Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Γεωργαλά, Σοφία	el
dc.contributor.author	Τσακίρης, Στυλιανός	el
dc.contributor.author	Μίχας, Τίμος	el
dc.date.accessioned	2015-05-09T18:49:45Z
dc.date.issued	2015-05-09
dc.identifier.uri	http://hdl.handle.net/11400/10042
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/11277950?dopt=AbstractPlus	en
dc.subject	ισοτρετινοΐνη
dc.subject	κυστική ακμή
dc.subject	δυσλιπιδαιμία
dc.subject	ομοκυστεΐνη
dc.subject	βιταμίνη Β6
dc.subject	βιταμίνη Β12
dc.subject	Isotretinoin
dc.subject	cystic acne
dc.subject	dyslipidemia
dc.subject	Homocysteine
dc.subject	Vitamin B6
dc.subject	Vitamin B12
dc.title	Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne	en
heal.type	journalArticle
heal.classification	Ανθρώπινη φυσιολογία
heal.classification	Δερματολογία
heal.classification	Human physiology
heal.classification	Dermatology
heal.classificationURI	N/A-Ανθρώπινη φυσιολογία
heal.classificationURI	N/A-Δερματολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85062884
heal.classificationURI	http://skos.um.es/unesco6/320106
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85068685
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh96011736
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143967
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85143970
heal.identifier.secondary	DOI: 10.1046/j.1365-4362.2001.00146.x
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2001-01
heal.bibliographicCitation	Schulpis, K.H., Karikas, G.A., Georgala, S., Michas, T. and Tsakiris, S. (2001) Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. International Journal of Dermatology. [Online] 40 (1). pp.33-36. Available from: http://www.ncbi.nlm.nih.gov [Accessed 09/05/2015]	en
heal.abstract	Background The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of enzymes, i.e. cystathionine-β-synthase. Increased blood levels of Hcy are associated with premature occlusive vascular disease. Objective The aim of this study was the evaluation of Hcy levels and the responsible vitamins for its metabolism in patients with CA on Iso treatment. Methods and Results Twenty-eight patients with CA were submitted to laboratory examinations before (Value 1) and after (Value 2) 45 days on Iso (0.5 mg/kg/24 h) therapy. Blood levels of Hcy and vitamin B6 were evaluated by HPLC methods, and folate and vitamin B12 using a commercial Kit. Hcy levels (Value 1 = 7.86 ± 1.6 μmol/L; Value 2 = 13.65 ± 3.3 μmol/L; P < 0.001) were statistically significantly increased in patients on treatment. Vitamins were unaltered, and lipids and liver enzymes increased. Significant correlation between Hcy levels, vitamins, and liver enzymes was found. Methionine loading tests performed in nine patient-volunteers showed an abnormal response post-treatment. Conclusions It is suggested that the elevated Hcy levels in patients after 45 days on Iso therapy could be due either to the ‘inhibition’ of cystathionine-β-synthase by the drug and/or their liver dysfunction. Daily vitamin supplementation along with frequent evaluations of Hcy blood levels are recommended for the prevention of a premature occlusive vascular disease.	en
heal.journalName	International Journal of Dermatology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false