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dc.contributor.author Σούλπη, Κλεοπάτρα el
dc.contributor.author Γεωργαλά, Σοφία el
dc.contributor.author Παπακωνσταντίνου, Ευάγγελος Δ. el
dc.contributor.author Μίχας, Τίμος el
dc.contributor.author Καρίκας, Γεώργιος-Αλβέρτος el
dc.date.accessioned 2015-05-09T21:28:26Z
dc.date.issued 2015-05-10
dc.identifier.uri http://hdl.handle.net/11400/10054
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://www.ncbi.nlm.nih.gov/pubmed/10325581?dopt=AbstractPlus en
dc.subject ισοτρετινοΐνη
dc.subject βλεννογονοδερματικές αντιδράσεις
dc.subject ξηροδερμία
dc.subject ερύθημα του δέρματος
dc.subject λιπίδια
dc.subject λιποπρωτεΐνες
dc.subject Isotretinoin
dc.subject mucocutaneous reactions
dc.subject Xerophthalmia
dc.subject Erythema
dc.subject lipids
dc.subject Lipoproteins
dc.title The effect of isotretinoin on biotinidase activity en
heal.type journalArticle
heal.classification Φαρμακευτική
heal.classification Δερματολογία
heal.classification Pharmacy
heal.classification Dermatology
heal.classificationURI **N/A**-Φαρμακευτική
heal.classificationURI **N/A**-Δερματολογία
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI http://skos.um.es/unesco6/320106
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85068685
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85148810
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85044740
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85077309
heal.identifier.secondary DOI: 10.1159/000029843
heal.dateAvailable 10000-01-01
heal.language en
heal.access forever
heal.recordProvider Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων el
heal.publicationDate 1999-01
heal.bibliographicCitation Schulpis, K.H., Georgala, S., Papakonstantinou, E.D., Michas, T. and Karikas, G.A. (1999) The Effect of Isotretinoin on Biotinidase Activity. Skin Pharmacology and Applied Skin Physiology. [Online] 12 (1-2). pp.28-33. Available from: http://www.ncbi.nlm.nih.gov [Accessed 09/05/2015] en
heal.abstract Background: Among the reaction and effects of isotretinoin, mucocutaneous reactions, xerosis and erythema of the skin as well as elevation of liver enzymes and lipids except high density lipoprotein have been reported. Objective: Since biotinidase is mainly produced in the liver and partial biotinidase deficiency causes dermatological manifestations, seborrheic dermatitis, alopecia etc., isotretinoin side effects in relation to biotinidase activity were studied. Methods: Forty-two (n = 42) patients with severe cystic acne had liver function tests, lipid estimations, serum biotin as well as biotinidase activity evaluations before (value 1) and on the 30th day (value 2) of treatment with isotretinoin monotherapy (Roaccutane 0.5 mg/kg/24 h). The same laboratory tests were evaluated in 50 controls only once. Moreover, the effect of isotretinoin on a known plasma biotinidase activity was evaluated after incubation in vitro with various concentrations of the drug. Results: A statistically significant elevation of liver enzymes and lipids, except high density lipoprotein, was observed at the end of this study. On the contrary, biotinidase activity was found to be significantly decreased as compared to the initial values (value 1 = 4.70 ± 0.89 nmol/min/l, value 2 = 2.50 ± 0.8 nmol/min/l, p < 0.001) and to controls (5.2 ± 0.9 nmol/min/l vs. value 2 = 2.50 ± 0.8 nmol/min/l, p < 0.001). Additionally, biotin levels showed no significant alterations and the in vitro incubation of the enzyme with various concentrations of the drug exhibited no effect on its activity. Conclusion: It is suggested that isotretinoin isomers-metabolites act in the liver, resulting in low biotinidase activity. en
heal.journalName Skin Pharmacology and Applied Skin Physiology en
heal.journalType peer-reviewed
heal.fullTextAvailability false


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες