In vitro influence of phenylalanine on acetylcholinesterase activity and DNA

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Τζαμουράνη, Ιωάννα	el
dc.date.accessioned	2015-05-09T22:04:51Z
dc.date.issued	2015-05-10
dc.identifier.uri	http://hdl.handle.net/11400/10056
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/9618943?dopt=AbstractPlus	en
dc.subject	ακετυλοχολινεστεράση
dc.subject	φαινυλαλανίνη
dc.subject	δεοξυριβονουκλεϊκό οξύ
dc.subject	Acetylcholinesterase
dc.subject	Phenylalanine
dc.subject	DNA
dc.title	In vitro influence of phenylalanine on acetylcholinesterase activity and DNA	en
heal.type	journalArticle
heal.classification	Χημεία
heal.classification	Γενετική
heal.classification	Chemistry
heal.classification	Genetics
heal.classificationURI	N/A-Χημεία
heal.classificationURI	N/A-Γενετική
heal.classificationURI	http://skos.um.es/unescothes/C00568
heal.classificationURI	http://zbw.eu/stw/descriptor/28854-5
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh92004641
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85100693
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85037008
heal.identifier.secondary	ISSN: 0939-5075
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	1998-03
heal.bibliographicCitation	Schulpis, K.H., Karikas, G.A. and Tjamouranis, J. (1998) In vitro influence of phenylalanine on acetylcholinesterase activity and DNA. Verlag der Zeitschrift für Naturforschung. [Online] 53 (3-4). pp.291-293. Available from: http://www.ncbi.nlm.nih.gov [Accessed 09/05/2015]	en
heal.abstract	Acetylcholinesterase (AChE) is a significant component of the membrane contributing to the permeability changes during synaptic transmission and conduction. Phenylketonuria is a group of metabolic disorders in which phenylalanine (Phe) is highly elevated in blood (up to 0.1 M) resulting in mental retardation etc. AChE activity was measured spectrophotometrically after incubation with various Phe concentrations. Phe interaction with DNA was evaluated with an established HPLC method. Phe was found to inhibit AChE almost 40%, at a concentration of 5 mM, whereas a 62.5% DNA peak exclusion (molecular interaction) was observed when Phe was incubated with DNA at a concentration of 3 mM. In addition the ratio of DNA: Phe determined the potency of the observed molecular effect.	en
heal.journalName	Verlag der Zeitschrift für Naturforschung	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true