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dc.contributor.author Gupta, M.P. en
dc.contributor.author Monge, A. en
dc.contributor.author Καρίκας, Γεώργιος-Αλβέρτος el
dc.contributor.author Lopez de Cerain, A. en
dc.contributor.author Solis, P.N. en
dc.date.accessioned 2015-05-10T19:32:33Z
dc.date.issued 2015-05-10
dc.identifier.uri http://hdl.handle.net/11400/10094
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://informahealthcare.com/doi/abs/10.1076/phbi.34.1.19.13180 en
dc.subject Φαρμακευτικά φυτά
dc.subject Τοξικότητα
dc.subject κυτταροτοξικότητα
dc.subject δεοξυριβονουκλεϊκό οξύ
dc.subject Παναμάς
dc.subject Botany, Medical
dc.subject Toxicology
dc.subject cytotoxicity
dc.subject DNA
dc.subject Panama
dc.title Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation en
heal.type journalArticle
heal.classification Φαρμακευτική
heal.classification Βοτανική
heal.classification Pharmacy
heal.classification Botany
heal.classificationURI **N/A**-Φαρμακευτική
heal.classificationURI **N/A**-Βοτανική
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85015976
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85016008
heal.keywordURI http://id.loc.gov/authorities/subjects/sh2002007679
heal.keywordURI http://lod.nal.usda.gov/31518
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85037008
heal.contributorName E De Leon en
heal.contributorName Trujillo, M. en
heal.contributorName Sanchez, C. en
heal.contributorName Suarez, O. en
heal.contributorName Wilson, F. en
heal.contributorName Montenegro, G. en
heal.contributorName Noriega, Y. en
heal.contributorName Santana, A.I. en
heal.contributorName Correa, M. en
heal.identifier.secondary DOI: 10.1076/phbi.34.1.19.13180
heal.dateAvailable 10000-01-01
heal.language en
heal.access forever
heal.recordProvider Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων el
heal.publicationDate 1996
heal.bibliographicCitation Gupta, M.P., Monge, A., Karikas, G.A., Lopez de Cerain, A., Solis, P.N. et al. (1996) Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation. International Journal of Pharmacognosy. [Online] 34 (1). pp.19-27. Available from: http://informahealthcare.com [Accessed 10/05/2015] en
heal.abstract Crude extracts from 20 Panamanian plants used in traditional medicine have been screened for brine shrimp toxicity, tumor inhibition, DNA-intercalation and cytotoxicity tests in a clonogenic assay in V79 suspension culture gassed with air or nitrogen. Of the 20 plant extracts, 8 (40%) proved active in DNA intercalation. The most active were the methanol extracts of Bidens pilosa (root), Jatropha curcas (leaf), Pereskia bleo (whole plant), Isertia hypoleuca (leaf), Cyperus luzulae (root), Vernonia patens (leaf and stem), Alibertia edulis (stem) and Justicia graciliflora (aerial parts). Sixteen (80%) of the 20 methanol plant extracts were active in potato disc tumor inhibition assay; Cyperus luzulae (root), Justicia graciliflora (aerial parts), Pereskia bleo (whole plant) and Vernonia patens (leaf and stem) being the most active. Cytotoxicity in the clonogenic assay was observed only in three plant extracts: Cyperus luzulae, Piper auritum and Psychotria correae, whereas high brine shrimp toxicity (LC 50 <100 p.p.m.) was observed in 13(65%) of the 20 plant extracts tested. These results appear to show a good correlation between the three bioassays: brine shrimp toxicity, tumor inhibition and DNA intercalation. The latter bioassay is rapid, economical, and can be used in activity guided fractionation of plant extracts. en
heal.journalName International Journal of Pharmacognosy en
heal.journalType peer-reviewed
heal.fullTextAvailability false


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες