Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation

dc.contributor.author	Gupta, M.P.	en
dc.contributor.author	Monge, A.	en
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Lopez de Cerain, A.	en
dc.contributor.author	Solis, P.N.	en
dc.date.accessioned	2015-05-10T19:32:33Z
dc.date.issued	2015-05-10
dc.identifier.uri	http://hdl.handle.net/11400/10094
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://informahealthcare.com/doi/abs/10.1076/phbi.34.1.19.13180	en
dc.subject	Φαρμακευτικά φυτά
dc.subject	Τοξικότητα
dc.subject	κυτταροτοξικότητα
dc.subject	δεοξυριβονουκλεϊκό οξύ
dc.subject	Παναμάς
dc.subject	Botany, Medical
dc.subject	Toxicology
dc.subject	cytotoxicity
dc.subject	DNA
dc.subject	Panama
dc.title	Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation	en
heal.type	journalArticle
heal.classification	Φαρμακευτική
heal.classification	Βοτανική
heal.classification	Pharmacy
heal.classification	Botany
heal.classificationURI	N/A-Φαρμακευτική
heal.classificationURI	N/A-Βοτανική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85015976
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85016008
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2002007679
heal.keywordURI	http://lod.nal.usda.gov/31518
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85037008
heal.contributorName	E De Leon	en
heal.contributorName	Trujillo, M.	en
heal.contributorName	Sanchez, C.	en
heal.contributorName	Suarez, O.	en
heal.contributorName	Wilson, F.	en
heal.contributorName	Montenegro, G.	en
heal.contributorName	Noriega, Y.	en
heal.contributorName	Santana, A.I.	en
heal.contributorName	Correa, M.	en
heal.identifier.secondary	DOI: 10.1076/phbi.34.1.19.13180
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	1996
heal.bibliographicCitation	Gupta, M.P., Monge, A., Karikas, G.A., Lopez de Cerain, A., Solis, P.N. et al. (1996) Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation. International Journal of Pharmacognosy. [Online] 34 (1). pp.19-27. Available from: http://informahealthcare.com [Accessed 10/05/2015]	en
heal.abstract	Crude extracts from 20 Panamanian plants used in traditional medicine have been screened for brine shrimp toxicity, tumor inhibition, DNA-intercalation and cytotoxicity tests in a clonogenic assay in V79 suspension culture gassed with air or nitrogen. Of the 20 plant extracts, 8 (40%) proved active in DNA intercalation. The most active were the methanol extracts of Bidens pilosa (root), Jatropha curcas (leaf), Pereskia bleo (whole plant), Isertia hypoleuca (leaf), Cyperus luzulae (root), Vernonia patens (leaf and stem), Alibertia edulis (stem) and Justicia graciliflora (aerial parts). Sixteen (80%) of the 20 methanol plant extracts were active in potato disc tumor inhibition assay; Cyperus luzulae (root), Justicia graciliflora (aerial parts), Pereskia bleo (whole plant) and Vernonia patens (leaf and stem) being the most active. Cytotoxicity in the clonogenic assay was observed only in three plant extracts: Cyperus luzulae, Piper auritum and Psychotria correae, whereas high brine shrimp toxicity (LC 50 <100 p.p.m.) was observed in 13(65%) of the 20 plant extracts tested. These results appear to show a good correlation between the three bioassays: brine shrimp toxicity, tumor inhibition and DNA intercalation. The latter bioassay is rapid, economical, and can be used in activity guided fractionation of plant extracts.	en
heal.journalName	International Journal of Pharmacognosy	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false