Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations

dc.contributor.author	Μπουζίκα, Μερόπη Δ.	el
dc.contributor.author	Παπαθανασόγλου, Ελισάβετ Δ.	el
dc.contributor.author	Γιαννακοπούλου, Μαργαρίτα	el
dc.contributor.author	Μπόζας, Ευάγγελος	el
dc.contributor.author	Μίτλεττον, Νίκος	el
dc.date.accessioned	2015-05-12T10:32:39Z
dc.date.available	2015-05-12T10:32:39Z
dc.date.issued	2015-05-12
dc.identifier.uri	http://hdl.handle.net/11400/10200
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S0143417912000741#?np=y	el
dc.subject	Stress (Physiology)
dc.subject	Neuropeptides
dc.subject	Neuropeptide Y
dc.subject	Lymphocytes
dc.subject	Στρες (Φυσιολογία)
dc.subject	Νευροπεπτίδια
dc.subject	Το νευροπεπτίδιο Υ
dc.subject	Substance P
dc.subject	Η ουσία Ρ
dc.subject	Λεμφοκύτταρα
dc.title	Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Nursing
heal.classification	Ιατρική
heal.classification	Νοσηλευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02778
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Νοσηλευτική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85128702
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85091156
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh90000480
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85079147
heal.contributorName	Μπότη, Σοφία	el
heal.contributorName	Πατηράκη - Κουρμπάνη, Ελισάβετ Ι.	el
heal.contributorName	Καραμπίνης, Ανδρέας	el
heal.identifier.secondary	doi:10.1016/j.npep.2012.07.007
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2013-02
heal.bibliographicCitation	Mpouzika, M. D.,Papathanassoglou, E. D., Giannakopoulou, M., Bozas, E., Middleton, N., et.al. (2013). Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations. ""Neuropeptides"" 47(1). February 2013, pp 25–36. Available from: http://www.sciencedirect.com/science/article/pii/S0143417912000741#?np=y. [Accessed 12/09/2012]	en
heal.abstract	Objective Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary–adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolactin) in critically ill individuals compared to matched controls, (b) associations with lymphocyte counts, (c) associations among stress neuropeptide levels, and (d) associations with perceived intensity of stress, critical illness severity and survival. Methods Correlational design with repeated measures. Thirty-six critically ill patients were followed up for 14 days compared to 36 healthy matched controls. Stress was assessed by the ICUESS scale. Correlations, cross-sectional comparisons and multiple regression models were pursued. Results For the first time, we report lower SP (Difference of means (DM) = 2928–3286 ng/ml, p < 0.001) and NPY (DM = 0.77–0.83 ng/ml, p < 0.0001) levels in critically ill individuals compared to controls. Cortisol levels were higher (DM = 140–173 ng/ml, p < 0.0001) and lymphocyte population counts (p < 0.002) were lower in patients throughout the study. NPY levels associated with lymphocyte (r = 0.411–0.664, p < 0.04), T-lymphocyte (r = 0.403–0.781, p < 0.05), T-helper (r = 0.492–0.690, p < 0.03) and T-cytotoxic cell populations (r = 0.39–0.740, p < 0.03). On day 1, cortisol levels exhibited associations with lymphocyte (r = −0.452, p = 0.01), T-cell (r = −0.446, p = 0.02), T-helper (r = −0.428, p = 0.026) and T-cytotoxic cells (r = −0.426, p = 0.027). ACTH levels associated with NK cell counts (r = 0.326–0.441, p < 0.05). Associations among stress neuropeptides levels were observed throughout (p < 0.05). ACTH levels associated with disease severity (r = 0.340–0.387, p < 0.005). A trend for an association between ACTH levels and intensity of stress was noted (r = 0.340, p = 0.057). Conclusion The significantly lowered NPY and SP levels and the associations with cortisol, ACTH and lymphocytes suggest that the role of these peptides in critical illness merit further investigation. Future studies need to address associations between these neuropeptides and functional immune cell responses and inflammatory markers in critical illness.	de
heal.journalName	Neuropeptides	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true