Cost-effectiveness of varenicline Versus Bupropion, Nicotine-Replacement Therapy, and Unaided Cessation in Greece

dc.contributor.author	Αθανασάκης, Κωνσταντίνος	el
dc.contributor.author	Ηγουμενίδης, Μιχαήλ	el
dc.contributor.author	Καραμπλή, Ελευθερία	el
dc.contributor.author	Βίτσου, Έλλη	el
dc.contributor.author	Συκαρά, Γεωργία	el
dc.date.accessioned	2015-05-23T10:09:27Z
dc.date.available	2015-05-23T10:09:27Z
dc.date.issued	2015-05-23
dc.identifier.uri	http://hdl.handle.net/11400/10953
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S0149291812004286	en
dc.subject	Smoking
dc.subject	Cost-effectiveness analysis
dc.subject	Κάπνισμα
dc.subject	Ανάλυση κόστους-αποτελεσματικότητας
dc.title	Cost-effectiveness of varenicline Versus Bupropion, Nicotine-Replacement Therapy, and Unaided Cessation in Greece	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Nursing
heal.classification	Ιατρική
heal.classification	Νοσηλευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02778
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Νοσηλευτική
heal.keywordURI	http://zbw.eu/stw/descriptor/11530-2
heal.contributorName	Κυριόπουλος, Γιάννης Η. (1945-)	el
heal.identifier.secondary	doi:10.1016/j.clinthera.2012.07.002
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής.	el
heal.publicationDate	2012
heal.bibliographicCitation	Athanasakis, K., Igoumenidis, M., Karampli, E., Vitsou, E., Sykara, G., et al. (August 2012). Cost-effectiveness of varenicline Versus Bupropion, Nicotine-Replacement Therapy, and Unaided Cessation in Greece. Clinical Therapeutics. 34(8). pp.1803-1814. Elsevier B.V: 2012. Available from: http://www.sciencedirect.com/science/article/pii/S0149291812004286 [Accessed 20/07/2012]	en
heal.abstract	Background Varenicline was designed to relieve symptoms of nicotine withdrawal, including cigarette craving, and to block the reinforcing effects of continued nicotine use. The cost-effectiveness of varenicline in some countries has not been studied. Objective The aim of this study was to compare the cost-effectiveness of varenicline to that of bupropion, nicotine-replacement therapy (NRT), and unaided cessation in the Greek health care setting. The analysis takes into account a societal security (third-party payer) perspective. Methods To perform the analyses of the benefits of smoking cessation in terms of smoking-related morbidity, mortality, and associated medical costs, a Markov model was used that simulated the progress of a hypothetical cohort of current smokers making a single attempt to quit smoking at the beginning of the timeframe of the analysis. The robustness of the results was assessed using a series of 1-way sensitivity analyses. Results Varenicline was associated with the potential prevention of 14.1, 14.2, and 35.1 additional cases of the 4 smoking-related diseases incorporated into the model, per 1000 smokers willing to quit, versus bupropion, NRT, and unaided cessation, respectively. Potentially avoided smoking-related deaths with varenicline were estimated at 3.24, 3.26, and 7.5 per 1000 quitters versus the 3 comparators. Varenicline led to a potential gain of 33.78, 33.91, and 83.97 QALYs per 1000 persons willing to make a quit attempt versus the 3 comparators. Varenicline was associated with cost-savings against both active comparators for the lifetime horizon. Overall, the cost per additional quitter with varenicline, considering only the costs of the smoking-cessation strategy, was €2659 (€1015) for a lifetime horizon compared with bupropion (NRT); however, when all direct costs were incorporated into the analysis, varenicline was cost-saving. Conclusion The findings from the present study suggest that, compared with the widely used treatment options bupropion and NRT, as well as unaided cessation, varenicline may enhance smoking-cessation treatment outcomes while substantially reducing the overall costs of smoking to the health care system.	en
heal.publisher	Elsevier B.V.	en
heal.journalName	Clinical Therapeutics	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true