Mechanisms of actions and health effects of organochlorine substances

dc.contributor.author	Γουρουντή, Κλεάνθη	el
dc.contributor.author	Λυκερίδου, Κατερίνα	el
dc.contributor.author	Πρωτόπαπα, Ευαγγελία Ε.	el
dc.contributor.author	Λάζαρης, Ανδρέας	el
dc.date.accessioned	2014-07-13T14:36:07Z
dc.date.available	2014-07-13T14:36:07Z
dc.date.issued	2014-07-13
dc.identifier.uri	http://hdl.handle.net/11400/1193
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.hsj.gr	en
dc.subject	Organochlorine substances
dc.subject	Dioxins
dc.subject	Endocrine disrupters
dc.subject	Hormone related cancers
dc.subject	Disorders of female reproductive system
dc.title	Mechanisms of actions and health effects of organochlorine substances	en
heal.type	journalArticle
heal.secondaryTitle	a review	en
heal.generalDescription	Review	en
heal.classification	Medicine
heal.classification	Ιατρική
heal.classificationURI	N/A-Medicine
heal.classificationURI	N/A-Ιατρική
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2008-06
heal.bibliographicCitation	Gourounti, K., Lykeridou, K., Protopapa, E., Lazaris, A.. (2008). Mechanisms of actions and health effects of organochlorine substances: a review. "Health Science Journal". 2 (2), 89-98.	el
heal.abstract	Organochlorines are a various group of synthetic chemicals that include polychlorinated biphenyls (PCBs), dibenzo- p- dioxiins and organochlorine pesticides. Human exposure to organochlorine substances may occur through inhalation of air, ingestion of food and water and skin absorption. Human exposure to organochlorines may occur not only during adulthood but also during prenatal and neonatal period. The developing fetus is exposed to organochlorines through placental transfer and the neonate through lactation. Organochlorine compounds exert many toxic effects on human health, such as, hormone related conditions (endometrisios, infertility), cancer of male and female reproductive system, developmental toxicity, neurotoxicity and immunotoxicity. The majority of these effects may be due to the ability of organochlorines to alter the levels of certain hormones, enzymes, growth factors and neurotransmitters and to induce key genes (cytochrome P-450 1A1 gene) involved in metabolism of steroids and xenobiotics. However, there is not always possible to identify causal relationships between organochlorine exposure and deleterious health effects. Limitations in the ability to identify or to quantify causal relationships are occasionally misinterpreted as evidence of safety. Frequently, governments have to wait until sufficient scientific information of harm is established before they act to prevent harm. However, failure to take precautionary action may have severe social, economic and health costs.	en
heal.publisher	Μαρβάκη, Χριστίνα	el
heal.journalName	Health Science Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true
heal.dateCreated	2008-04