Burden of organochlorine substances as a risk factor of breast cancer

dc.contributor.author	Γουρουντή, Κλεάνθη	el
dc.contributor.author	Λάζαρης, Ανδρέας	el
dc.date.accessioned	2014-07-20T09:53:35Z
dc.date.available	2014-07-20T09:53:35Z
dc.date.issued	2014-07-20
dc.identifier.uri	http://hdl.handle.net/11400/1457
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.hsj.gr	en
dc.subject	Organochlorine compounds
dc.subject	Dioxins
dc.subject	Hormone receptors
dc.subject	Endocrine disrupting chemicals
dc.subject	Breast--Cancer--Adjuvant treatment
dc.subject	Breast--Cancer--Risk factors
dc.subject	Οργανοχλωριούχος ένωση
dc.subject	Διοξίνη
dc.subject	Ενδοκρινείς διαταραχές
dc.subject	Καρκίνος του μαστού
dc.subject	Κίνδυνος
dc.subject	Ορμόνες
dc.title	Burden of organochlorine substances as a risk factor of breast cancer	en
heal.type	journalArticle
heal.generalDescription	Review article	en
heal.classification	Medicine
heal.classification	Gynecology
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Γυναικολογία
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85058092
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Γυναικολογία
heal.classificationURI	N/A-Ογκολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85095542
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85038140
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85061978
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2008020233
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2010008350
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2009117568
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2009-03
heal.bibliographicCitation	Gourounti, K. & Lazaris, A. (March 2009). Burden of organochlorine substances as a risk factor of breast cancer. “Health Science Journal”. 3 (1). p. 19-31.	en
heal.abstract	Background: Organochlorines are a various group of synthetic chemicals that include polychlorinated biphenyls (PCBs), dibenzo- p- dioxins/ polychlorinated dibenzofurans (PCDDs/ PCDFs or dioxins) and organochlorine pesticides, such as dichlorodiphenyl-trichloroethane (DDT), lindane, aldrin and dieldrin. As many organochlorines and their metabolites have carcinogenic and the weak hormonal (estrogenic and anti-estrogenic) effects, a possible association between breast cancer risk and exposure to organochlorines has been hypothesized. It has been estimated that well established risk factors explain only about 41% of breast cancer cases, with the remainder cases due to unidentified causes. Since known risk factors for breast cancer account only for about half of all cases, there has been continued interest in the role of organochlorines and other environmental pollutants in unexplained breast cancer. Methods: The literature concerning the association between organochlorines and risk of breast cancer was reviewed. Relevant studies were identified by searching the following databases: the Cochrane Library, Medline, Embase and PubMed. Studies that met the quality criteria included in the review. Results: Association between organochlorines, such as DDT and PCBs, and breast cancer risk has been reported in a number of epidemiological studies since 1976. The association of PCBs and DDE with breast cancer has been investigated in a series of retrospective case-control studies and in prospective nested case-control studies. In general, the individual epidemiological studies that have been conducted to date and are presented in this review, do not support a positive association between body burdens of single organochlorines and the development of breast cancer. However, the quality of available scientific information is low because the majority of epidemiological studies that have been conducted till now have many limitations and weaknesses. Conclusion: This review shows that high concentration of single organochlorine compounds are not important predictors for breast cancer. However, a hypothetical association between organochlorine substances and risk of breast cancer cannot be investigated on the basis of single substances levels. The possible synergetic, antagonistic or additive interactions between the substances should be considered. Further research on interactions between organochlorines and other xenoestrogens and natural estrogens is recommended.	en
heal.publisher	Μαρβάκη, Χριστίνα	el
heal.journalName	Health Science Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true
heal.dateCreated	2009-01