Objective: The purpose of this survey was the study of the occurrence of anxiety and depression symptoms in patients with Type 2 Diabetes Mellitus with regard to sex and body mass index (BMI). Material and method: 310 individuals with type 2 Diabetes mellitus participated in the study. Their demographic and clinical features were examined. The self–completed questionnaire ΗADS was used for anxiety and depression level evaluation. Results: 56% of the participants were women (n=174), while men percentage was 44% (n=136). Percentages of anxiety symptoms in women were three times higher in comparison to men, 62% (n=136) of women were presented with HADS-A>8 in contrast to 21% (n=29) of men (p<0,001). Women had a twofold percentage of depression symptomatology than men, as 41.4% (n=72) of women were presented with a HADS-A>8 in comparison to men’s 17,8 % (n=24).When the relation between sex, age and Body Mass Index (BMI) and depression-anxiety symptoms was examined, it was shown that high BMI favors the occurrence of modest or severe symptomatology, as risk increases for any additional BMI unit. Conclusion: The occurrence of anxiety and depression symptoms is strongly related to the sex of individuals with Type 2 Diabetes mellitus, as well as with the Body Mass Index.