Show simple item record Νικολοπούλου - Γκρεκ, Ιωάννα el Γιατράκου, Σοφία el Δαμοράκη, Γεωργία el Πιστίκη, Αικατερίνη Κ. el Καλδριμίδης, Φίλιππος Χ. el 2015-06-05T15:16:58Z 2015-06-05T15:16:58Z 2015-06-05
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri *
dc.source en
dc.subject Acne
dc.subject Adolescent
dc.subject Adult
dc.subject Base Sequence
dc.subject case-control studies
dc.subject DNA primers
dc.subject Female
dc.subject Gene frequency
dc.subject Humans
dc.subject Male
dc.subject Polymerase chain reaction
dc.subject polymorphism
dc.subject Single Nucleotide
dc.subject Toll-Like Receptor 4
dc.subject Young Adult
dc.subject Ακμή
dc.subject Έφηβος
dc.subject Ενήλικας
dc.subject Αλληλουχία βάσης
dc.subject Μελέτες ασθενών
dc.subject Ενάρκτες DNA
dc.subject Θηλυκό
dc.subject Συχνότητα γονιδίου
dc.subject Άνθρωποι
dc.subject Αρσενικό
dc.subject Αλυσιδωτή αντίδραση πολυμεράσης
dc.subject Πολυμορφισμός
dc.subject Μονόκλινο νουκλεοτίδιο
dc.subject Υποδοχέας Toll 4
dc.subject Νεαρός ενήλικας
dc.title Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata en
heal.type journalArticle
heal.classification Medicine
heal.classification Dermatology
heal.classification Ιατρική
heal.classification Δερματολογία
heal.classificationURI **N/A**-Ιατρική
heal.classificationURI **N/A**-Δερματολογία
heal.contributorName Γιαμαρέλλος - Μπούρμπουλης, Ευάγγελος el
heal.contributorName Σταυριανέας, Νικόλαος, Γ. el
heal.identifier.secondary DOI: 10.1111/j.1468-3083.2011.04338.x
heal.language en
heal.access campus
heal.recordProvider Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας el
heal.publicationDate 2012-12
heal.bibliographicCitation Grech, I., Giatrakou, S., Damoraki, G., Pistiki, A., Kaldrimidis, P., et al. (2012) Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. "Journal of the European Academy of Dermatology and Venereology", 26 (12), p. 1538-1543. Available from: [Accessed: 05/06/2015]. en
heal.abstract Background: Former studies have shown that Propionibacterium acnes may stimulate expression of toll-like receptor 4 (TLR4) in keratinocytes of patients with acne vulgaris. Objective: To investigate the impact of single nucleotide polumorphisms (SNPs) of the TLR4 gene in acne vulgaris. Methods: Genomic DNA was isolated from 191 patients with acne vulgaris and 75 healthy controls. Asp299Gly and Thr399Ile SNPs were defined after cutting of the PCR products by restriction enzymes. Sebum of lesions was cultured for P. acnes. Results: No differences in SNP allele frequencies were found between patients and healthy controls. 46.5% of carriers of wild-type alleles were suffering from acne conglobata compared with 28.6% of carriers of SNP alleles (P = 0.040). After adjusting for gender, family history of acnes, intake of any therapy and skin isolation of P. acnes, carriage of TLR4 gene SNPs was the only independent variable linked with a protective role against acne conglobata (OR = 0.269, P = 0.014). No differences were found in the amount of pro-inflammatory cytokines released by peripheral blood mononuclear cells isolated from patients with acne conglobata carrying only wild-type alleles and SNP alleles. Conclusions: Carriage of gene SNPs is protective against the development of acne conglobata even in the presence of P. acnes. en
heal.publisher Ring, Johannes de
heal.journalName Journal of the European Academy of Dermatology and Venereology en
heal.journalType peer-reviewed
heal.fullTextAvailability true

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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες