Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata

dc.contributor.author	Νικολοπούλου - Γκρεκ, Ιωάννα	el
dc.contributor.author	Γιατράκου, Σοφία	el
dc.contributor.author	Δαμοράκη, Γεωργία	el
dc.contributor.author	Πιστίκη, Αικατερίνη Κ.	el
dc.contributor.author	Καλδριμίδης, Φίλιππος Χ.	el
dc.date.accessioned	2015-06-05T15:16:58Z
dc.date.available	2015-06-05T15:16:58Z
dc.date.issued	2015-06-05
dc.identifier.uri	http://hdl.handle.net/11400/15137
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083	en
dc.subject	Acne
dc.subject	Adolescent
dc.subject	Adult
dc.subject	Base Sequence
dc.subject	case-control studies
dc.subject	DNA primers
dc.subject	Female
dc.subject	Gene frequency
dc.subject	Humans
dc.subject	Male
dc.subject	Polymerase chain reaction
dc.subject	polymorphism
dc.subject	Single Nucleotide
dc.subject	Toll-Like Receptor 4
dc.subject	Young Adult
dc.subject	Ακμή
dc.subject	Έφηβος
dc.subject	Ενήλικας
dc.subject	Αλληλουχία βάσης
dc.subject	Μελέτες ασθενών
dc.subject	Ενάρκτες DNA
dc.subject	Θηλυκό
dc.subject	Συχνότητα γονιδίου
dc.subject	Άνθρωποι
dc.subject	Αρσενικό
dc.subject	Αλυσιδωτή αντίδραση πολυμεράσης
dc.subject	Πολυμορφισμός
dc.subject	Μονόκλινο νουκλεοτίδιο
dc.subject	Υποδοχέας Toll 4
dc.subject	Νεαρός ενήλικας
dc.title	Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Dermatology
heal.classification	Ιατρική
heal.classification	Δερματολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unesco6/320106
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Δερματολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85000560
heal.keywordURI	http://lod.nal.usda.gov/137073
heal.keywordURI	http://lod.nal.usda.gov/34216
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85053735
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh89002539
heal.keywordURI	http://lod.nal.usda.gov/8592
heal.contributorName	Γιαμαρέλλος - Μπούρμπουλης, Ευάγγελος	el
heal.contributorName	Σταυριανέας, Νικόλαος, Γ.	el
heal.identifier.secondary	DOI: 10.1111/j.1468-3083.2011.04338.x
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2012-12
heal.bibliographicCitation	Grech, I., Giatrakou, S., Damoraki, G., Pistiki, A., Kaldrimidis, P., et al. (2012) Single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. "Journal of the European Academy of Dermatology and Venereology", 26 (12), p. 1538-1543. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2011.04338.x/abstract [Accessed: 05/06/2015].	en
heal.abstract	Background: Former studies have shown that Propionibacterium acnes may stimulate expression of toll-like receptor 4 (TLR4) in keratinocytes of patients with acne vulgaris. Objective: To investigate the impact of single nucleotide polumorphisms (SNPs) of the TLR4 gene in acne vulgaris. Methods: Genomic DNA was isolated from 191 patients with acne vulgaris and 75 healthy controls. Asp299Gly and Thr399Ile SNPs were defined after cutting of the PCR products by restriction enzymes. Sebum of lesions was cultured for P. acnes. Results: No differences in SNP allele frequencies were found between patients and healthy controls. 46.5% of carriers of wild-type alleles were suffering from acne conglobata compared with 28.6% of carriers of SNP alleles (P = 0.040). After adjusting for gender, family history of acnes, intake of any therapy and skin isolation of P. acnes, carriage of TLR4 gene SNPs was the only independent variable linked with a protective role against acne conglobata (OR = 0.269, P = 0.014). No differences were found in the amount of pro-inflammatory cytokines released by peripheral blood mononuclear cells isolated from patients with acne conglobata carrying only wild-type alleles and SNP alleles. Conclusions: Carriage of gene SNPs is protective against the development of acne conglobata even in the presence of P. acnes.	en
heal.publisher	Ring, Johannes	de
heal.journalName	Journal of the European Academy of Dermatology and Venereology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true