Modulation of lymphangiogenesis

dc.contributor.author	Γιαννακοπούλου, Ελένη	el
dc.date.accessioned	2015-06-05T15:59:15Z
dc.date.available	2015-06-05T15:59:15Z
dc.date.issued	2015-06-05
dc.identifier.uri	http://hdl.handle.net/11400/15143
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4604	en
dc.subject	Cyclo-oxygenase
dc.subject	Lymphangiogenesis
dc.subject	Nonsteroidal anti-inflammatory agents
dc.subject	Tumor metastasis
dc.subject	VEGF-C
dc.subject	Κυκλοοξυγενάση
dc.subject	Λεμφαγγειογένεση
dc.subject	Μη στεροειδής αντι-φλεγμονώδεις παράγοντες
dc.subject	Μετάσταση όγκου
dc.subject	Αγγειακός ενδοθηλιακός αυξητικός παράγοντας C
dc.title	Modulation of lymphangiogenesis	en
heal.type	journalArticle
heal.secondaryTitle	a new target for aspirin and other nonsteroidal anti-inflammatory agents? a systematic review	en
heal.classification	Medicine
heal.classification	Cardiology
heal.classification	Ιατρική
heal.classification	Καρδιολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85020214
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Καρδιολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85092365
heal.identifier.secondary	DOI: 10.1177/0091270011431066
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2012-11
heal.bibliographicCitation	Yiannakopoulou, E. (2012) Modulation of lymphangiogenesis: a new target for aspirin and other nonsteroidal anti-inflammatory agents? a systematic review. "The Journal of Clinical Pharmacology", 52 (11), p. 1749 - 1754. Available from: http://onlinelibrary.wiley.com/doi/10.1177/0091270011431066/abstract [Accessed: 05/06/2015].	en
heal.abstract	Recent studies have implicated that lymphangiogenesis plays a role in the development of metastasis in experimental cancer models and in certain types of human tumors. Epidemiological and laboratory data suggest that non steroidal anti-inflammatory agents (NSAIDs) have antitumor activities, although the mechanisms have not been elucidated. This systematic review aimed to synthesize data on the effect of aspirin and other NSAIDs on lymphangiogenesis. In particular, an answer was attempted to be found for the following primary questions: Is there an effect of aspirin and NSAIDs on lymphangiogenesis? If yes, is this effect mediated through COX-II inhibition or through COX-II-independent mechanisms? Electronical databases were searched with the appropriate search terms for the period from 1966 up to and including February 2011. The few identified experimental trials indicated that aspirin and other NSAIDs inhibit lymphangiogenesis, with a potential decrease in metastatic spread, possibly through COX-II-dependent regulation of VEGF-C expression. COX-II-independent mechanisms of inhibition of lymphangiogenesis by salicylates and the other NSAIDs have not been investigated. Although further research validation is needed, this proposed effect of NSAIDs might have therapeutic implications in chemoprevention, adjuvant chemotherapy, and treatment of metastatic disease.	en
heal.publisher	Bertino, Joseph S., Jr.	en
heal.journalName	The Journal of Clinical Pharmacology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true