Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the 99mTc (CO) 3 + core

dc.contributor.author	Μπουζιώτη, Πηνελόπη	el
dc.contributor.author	Γούρνη, Ελένη	el
dc.contributor.author	Πάτσης, Γεώργιος	el
dc.contributor.author	Ψιμαδάς, Δημήτριος	el
dc.contributor.author	Ζήκος, Χρήστος	el
dc.date.accessioned	2015-06-05T17:03:01Z
dc.date.available	2015-06-05T17:03:01Z
dc.date.issued	2015-06-05
dc.identifier.uri	http://hdl.handle.net/11400/15163
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com	en
dc.subject	Radiolabeling
dc.subject	Radiopharmaceuticals
dc.subject	Ραδιοσήμανση
dc.subject	Ραδιοφάρμακα
dc.title	Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the 99mTc (CO) 3 + core	el
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Medical physics
heal.classification	Ιατρική
heal.classification	Ιατρική φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85083001
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ιατρική φυσική
heal.contributorName	Φάνη, Μελπωμένη	el
heal.contributorName	Ξανθόπουλος, Σταύρος	el
heal.contributorName	Λούντος, Γεώργιος	el
heal.contributorName	Παραβάτου - Πετσωτά, Μαρία	el
heal.contributorName	Λιβανίου, Ευαγγελία	el
heal.contributorName	Βαρβαρίγου, Αλεξάνδρα	el
heal.contributorName	Πιρμέττης, Ιωάννης	el
heal.contributorName	Παπαδόπουλος, Μηνάς	el
heal.identifier.secondary	DOI: 10.1016/j.bmc.2013.08.010
heal.language	en
heal.access	campus
heal.publicationDate	2013
heal.bibliographicCitation	Bouziotis, P., Gourni, E., Patsis, G., Psimadas, D., Zikos, C. et al. (2013) Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the 99mTc (CO) 3 + core. "Bioorganic and Medicinal Chemistry", 21 (21), p.6699-6707	el
heal.abstract	Bombesin is a neuropeptide widely studied due to its ability to target various types of cancers. Technetium-99m on the other hand is ideal for diagnostic tumor targeting. The aim of the present study is the investigation of the coupling of the ligand (S)-(2-(2′-pyridyl)ethyl)-d,l-cysteine with the BN-peptide Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met(CONH 2) through the spacer aminohexanoic acidand the labeling of the resulting derivative MBN with the synthon [M(CO)3(H 2O)3]+ (M = 99mTc, Re). The peptide was synthesized according to the SPPS method, purified and characterized by ESI-MS. The new 99mTc-labeled biomolecule was stable in vitro, showed high affinity for the human GRP receptor expressed in PC3 cells and the rate of internalization was found to be time-dependent tissue distribution of the radiopeptide was evaluated in normal mice and in prostate cancer experimental models and significant radioactivity uptake was observed in the pancreas of normal mice as well as in PC3 tumors. Dynamic studies of the radiopeptide showed satisfactory tumor images.	en
heal.publisher	Elsevier	en
heal.journalName	Bioorganic and Medicinal Chemistry	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true