Optimization of a gamma imaging probe for axillary sentinel lymph mapping

dc.contributor.author	Γεωργίου, Μαρία	el
dc.contributor.author	Λούντος, Γεώργιος	el
dc.contributor.author	Δαυίδ, Στράτος Λ.	el
dc.contributor.author	Παπαδημήτρουλας, Παναγιώτης Γ.	el
dc.contributor.author	Λιάκου, Π.	el
dc.date.accessioned	2015-06-05T17:21:58Z
dc.date.available	2015-06-05T17:21:58Z
dc.date.issued	2015-06-05
dc.identifier.uri	http://hdl.handle.net/11400/15167
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://iopscience.iop.org/1748-0221/	en
dc.subject	Gamma camera
dc.subject	SPECT
dc.subject	PET PET/CT
dc.subject	Coronary CT angiography (CTA)
dc.subject	Intraoperative probes
dc.subject	Κάμερα Γάμμα
dc.subject	Υπολογιστική τομογραφία εκπομπής μονήρους φωτονίου
dc.subject	Τομογραφία εκπομπής ποζιτρονίων/ αξονική τομογραφία
dc.subject	Αξονική στεφανιαία αγγειογραφία
dc.subject	Διεγχειρητικές ανιχνευτές
dc.title	Optimization of a gamma imaging probe for axillary sentinel lymph mapping	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Technology
heal.classification	Ιατρική
heal.classification	Τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/10470-6
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Τεχνολογία
heal.contributorName	Γεωργούλιας, Παναγιώτης	el
heal.identifier.secondary	DOI: 10.1088/1748-0221/7/09/P09010
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2012-09
heal.bibliographicCitation	Georgiou, M., Loudos, G., David, S., Papadimitroulas, P., Liakou, P., et al. (2012) Optimization of a gamma imaging probe for axillary sentinel lymph mapping. "Journal of Instrumentation", 7 (3). Available from: http://iopscience.iop.org/1748-0221/7/09/P09010/ [Accessed: 05/06/2015].	en
heal.abstract	Sentinel lymph node (SLN) mapping is a technique for assessing whether early-stage invasive breast cancer has metastasized, thus determining prognosis and treatment options. SLN identification is achieved using the blue-dye and radioactive colloids techniques, which are sometimes combined with lymphoscintigraphy. Furthermore, intra-operative gamma acoustic probes, as well as gamma imaging probes are used during surgery. The purpose of this study is the construction of a gamma probe for sentinel lymph node imaging and its optimization in terms of sensitivity with respect to spatial resolution. The reference probe has small field of view (2.5 × 2.5 cm2) and is based on a position sensitive photomultiplier tube (PSPMT) coupled to a pixellated CsI(Tl) scintillator. Following experimental validation, we simulated the system using the GATE Monte Carlo toolkit (GATE v6.1) and modeled various collimator geometries, in order to evaluate their performance and propose the optimal configuration. The constraints of the proposed gamma imaging probe are i) sensitivity close to 2 cps/kBq and ii) spatial resolution equal to 6 mm at 2 cm source-to-collimator distance and ~ 10 mm at 5 cm. An integrated structure that achieves those requirements is a tungsten collimator with 2 × 2 mm2square holes, 16 mm thickness, 0.15 mm septa, where each CsI(Tl) 2 × 2 × 5 mm3 crystal pixel is placed inside the collimator.	en
heal.publisher	Allport, Phil	en
heal.journalName	Journal of Instrumentation	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true