3D calculation of absorbed dose for 131I-targeted radiotherapy

dc.contributor.author	Saeedzadeh, E.	en
dc.contributor.author	Sarkar, Saeed	en
dc.contributor.author	Abbaspour-Tehrani Fard, Ali	en
dc.contributor.author	Ay, Mohammadreza	en
dc.contributor.author	Khosravi, Hamid Reza	en
dc.date.accessioned	2015-06-05T22:40:03Z
dc.date.available	2015-06-05T22:40:03Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15241
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://rpd.oxfordjournals.org/	en
dc.subject	Computer Simulation
dc.subject	Iodine Radioisotopes
dc.subject	Liver Neoplasms
dc.subject	Radiotherapy Dosage
dc.subject	Radiotherapy Planning
dc.subject	Computer-Assisted
dc.subject	Tomography
dc.subject	Προσομοίωση σε υπολογιστή
dc.subject	Ιώδιο ραδιοϊσοτόπων
dc.subject	Νεοπλάσματα Ηπατος
dc.subject	Δόση ραδιοθεραπείας
dc.subject	Πρόγραμμα ραδιοθεραπείας
dc.subject	Με τη βοήθεια υπολογιστή
dc.subject	Τομογραφία
dc.title	3D calculation of absorbed dose for 131I-targeted radiotherapy	en
heal.type	journalArticle
heal.secondaryTitle	a monte carlo study	en
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unesco6/320713
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.contributorName	Λούντος, Γεώργιος	el
heal.identifier.secondary	DOI: 10.1093/rpd/ncr411
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	en
heal.publicationDate	2012-07
heal.bibliographicCitation	Saeedzadeh, E., Sarkar, S., Abbaspour Tehrani-Farda, A., Ay, M., Khosravi, H., et al. (2012) 3D calculation of absorbed dose for 131I-targeted radiotherapy: a monte carlo study. "Radiation Protection Dosimetry", 150 (3), p. 298-305. Available from: http://rpd.oxfordjournals.org/content/150/3/298 [Accessed: 05/06/2015].	en
heal.abstract	Various methods, such as those developed by the Medical Internal Radiation Dosimetry (MIRD) Committee of the Society of Nuclear Medicine or employing dose point kernels, have been applied to the radiation dosimetry of 131I radionuclide therapy. However, studies have not shown a strong relationship between tumour absorbed dose and its overall therapeutic response, probably due in part to inaccuracies in activity and dose estimation. In the current study, the GATE Monte Carlo computer code was used to facilitate voxel-level radiation dosimetry for organ activities measured in an 131I-treated thyroid cancer patient. This approach allows incorporation of the size, shape and composition of organs (in the current study, in the Zubal anthropomorphic phantom) and intra-organ and intra-tumour inhomogeneities in the activity distributions. The total activities of the tumours and their heterogeneous distributions were measured from the SPECT images to calculate the dose maps. For investigating the effect of activity distribution on dose distribution, a hypothetical homogeneous distribution of the same total activity was considered in the tumours. It was observed that the tumour mean absorbed dose rates per unit cumulated activity were 0.65E−5 and 0.61E−5 mGY MBq−1 s−1 for the uniform and non-uniform distributions in the tumour, respectively, which do not differ considerably. However, the dose–volume histograms (DVH) show that the tumour non-uniform activity distribution decreases the absorbed dose to portions of the tumour volume. In such a case, it can be misleading to quote the mean or maximum absorbed dose, because overall response is likely limited by the tumour volume that receives low (i.e. non-cytocidal) doses. Three-dimensional radiation dosimetry, and calculation of tumour DVHs, may lead to the derivation of clinically reliable dose–response relationships and therefore may ultimately improve treatment planning as well as response assessment for radionuclide therapy.	en
heal.publisher	Zoetelief, J.	en
heal.journalName	Radiation Protection Dosimetry	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true