Experimental and simulation studies for the optimization of dedicated scintimammography cameras

dc.contributor.author	Γεωργίου, Μαρία	el
dc.contributor.author	Δαυίδ, Στράτος	el
dc.contributor.author	Λούντος, Γεώργιος	el
dc.contributor.author	Τσούγος, Ιωάννης Μ.	el
dc.contributor.author	Γεωργούλιας, Παναγιώτης	el
dc.date.accessioned	2015-06-05T22:55:35Z
dc.date.available	2015-06-05T22:55:35Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15242
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://iopscience.iop.org/1748-0221	en
dc.subject	Gamma camera
dc.subject	Single-photon emission computed tomography
dc.subject	PET PET/CT
dc.subject	Coronary CT angiography (CTA)
dc.subject	Gamma ray detectors
dc.subject	Simulation methods and programs
dc.subject	X-ray mammography and scinto
dc.subject	MRI-mammography
dc.subject	Γάμμα κάμερα
dc.subject	Υπολογιστική τομογραφία εκπομπής μονήρους φωτονίου
dc.subject	Τομογραφία εκπομπής ποζιτρονίων/ αξονική τομογραφία
dc.subject	Ανιχνευτές Γάμμα ακτίνων
dc.subject	Μέθοδοι και προγράμματα προσομοίωσης
dc.subject	Μαστογραφια Ακτίνων Χ
dc.subject	Αξονική μαστογραφία
dc.title	Experimental and simulation studies for the optimization of dedicated scintimammography cameras	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Technology
heal.classification	Ιατρική
heal.classification	Τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/10470-6
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Τεχνολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2006001159
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh97000760
heal.identifier.secondary	DOI: 10.1088/1748-0221/7/01/P01011
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2012-01
heal.bibliographicCitation	Georgiou, M., David, S., Loudos, G., Tsougos, I. and Georgoulias, P. (2012) Experimental and simulation studies for the optimization of dedicated scintimammography cameras. "Journal of Instrumentation", 7 (1). Available from: http://iopscience.iop.org/1748-0221/7/01/P01011/ [Accessed: 05/06/2015].	en
heal.abstract	The main drawback of scintimammography with conventional gamma cameras is the large distance between detector and breast, which limits imaging performance and adds significant background noise from the heart and other organs. These limitations can be minimized by dedicated gamma cameras placed in tight contact with the breast. The purpose of this study was to determine the lowest Tumor-to-Background (T:B) ratio for detectable lesions and the smallest lesions that can be imaged with a dedicated system. The system is based on an R3292 position sensitive photomultiplier tube (PSPMT) from Hamamatsu, coupled to a 10 cm in diameter CsI(Tl) crystal and a general purpose collimator with hexagonal holes. Two crystals were assessed, with pixel size of 2 × 2 mm2 and 3 × 3 mm2. The experimental setup consists of a cylindrical breast phantom, cylindrical tumor phantoms positioned inside the breast phantom at various depths, and a heart phantom. The same setup, as well as some additional tumor phantoms, were modeled with the GATE simulation toolkit, following the validation of the entire system. A 20% energy window and the Dual Energy Window Subtraction Method (DEWSM) for scatter correction were applied in experimental and simulation data. In all measurements 99mTc was used. Signal to Noise Ratio (SNR) and contrast were measured in all experiments and used for quantification of results. Experimental and simulation results show that the lowest T:B ratio that can be detected is 2:1 with tumor phantom volume ≥ 0.25 ml at 1 cm depth. The smallest volume of a tumor phantom that can be detected is 0.04 ml with T:B ratio equal to 9:1 at 1 cm depth.	en
heal.journalName	Journal of Instrumentation	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true