Pharmacogenomics of breast cancer targeted therapy

dc.contributor.author	Γιαννακοπούλου, Ελένη	el
dc.date.accessioned	2015-06-06T09:53:37Z
dc.date.available	2015-06-06T09:53:37Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15267
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.eurekaselect.com/651/journal/recent-patents-dna-amp-gene-sequences	en
dc.subject	Anastrozole
dc.subject	Anti-angiogenetic agents
dc.subject	Aromatase inhibitors
dc.subject	Bevacizumab
dc.subject	Breast cancer
dc.subject	CYP2D6 polymorphisms
dc.subject	Estrogen--Receptors
dc.subject	Exemestane
dc.subject	HER2 inhibitors
dc.subject	Patents
dc.subject	Pharmacogenomics
dc.subject	Tamoxifen
dc.subject	Targeted therapy
dc.subject	Trastuzumab
dc.subject	Αναστροζόλη
dc.subject	Αντι-αγγειογενετικά μέσα
dc.subject	Αναστολείς αρωματάσης
dc.subject	Μπεβασιζουμάμπη
dc.subject	Καρκίνος μαστού
dc.subject	Πολυμορφισμοί CYP2D6
dc.subject	Υποδοχείς οιστρογόνων
dc.subject	Εξεμεστάνη
dc.subject	Αναστολείς HER2
dc.subject	Πατέντες
dc.subject	Φαρμακογενωμική
dc.subject	Ταμοξιφένη
dc.subject	Στοχευμένη θεραπεία
dc.subject	Τραστουζουμάμπη
dc.title	Pharmacogenomics of breast cancer targeted therapy	en
heal.type	journalArticle
heal.secondaryTitle	focus on recent patents	en
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unesco6/320713
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2007003617
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85045014
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh99000126
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85132219
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh98002670
heal.identifier.secondary	DOI: 10.2174/187221512799303118
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2012-04
heal.bibliographicCitation	Yiannakopoulou, E. (2012) Pharmacogenomics of breast cancer targeted therapy: focus on recent patents. "Recent Patents on DNA and Gene Sequences", 6 (1), p. 33-46. Available from: http://www.eurekaselect.com/94991/article [Accessed: 06/06/2015].	en
heal.abstract	Adjuvant endocrine therapy as well as other forms of targeted therapy such as HER2 inhibitors and antiangiogenic agents reduce the risk of recurrence and improve survival among women with hormone receptor positive breast cancer. However, a significant percentage of women who receive targeted therapy as adjuvant or metastatic treatment do not benefit from this therapy, while a number of women who initially respond will eventually develop disease progression and relapse while on therapy. The observed variability in treatment response to targeted breast cancer treatment could be partly explained by pharmacogenomics. This paper reviews evidence on the role of pharmacogenomics of breast targeted therapy focusing on the clinical relevance of genetic variation. In particular, this article reviews the role of pharmacogenomics of tamoxifen, aromatase inhibitors, HER-2 inhibitors and anti-angiogenic agents. In addition, recent patents in the field are presented that provide promising steps in the field of personalized treatment of breast cancer, although future studies are needed for determining the clinical benefit of the proposed inventions. Finally, we present a testable hypothesis to aide the search for biologically meaningful genetic variation Specifically, we suggest the publication of negative results in the field of pharmacogenomics and pharmacoproteomics, will benefit future research in the field.	en
heal.journalName	Recent Patents on DNA and Gene Sequences	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true