A comparison of hormonal profiles between breast cancer and benign breast disease

dc.contributor.author	Λάγιου, Παγώνα	el
dc.contributor.author	Λάγιου, Αρετή	el
dc.contributor.author	Σαμόλη, Ευαγγελία	el
dc.contributor.author	Ζουρνά, Παντελίνα	el
dc.contributor.author	Μπαρμπούνη, Αναστασία	el
dc.date.accessioned	2015-06-06T15:03:33Z
dc.date.available	2015-06-06T15:03:33Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15323
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://annonc.oxfordjournals.org	en
dc.subject	Καλοήθεις παθήσεις του μαστού
dc.subject	Καρκίνος του μαστού
dc.subject	Στεροειδείς ορμόνες
dc.subject	Steroid hormones
dc.title	A comparison of hormonal profiles between breast cancer and benign breast disease	en
heal.type	journalArticle
heal.secondaryTitle	a case-control study	en
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.contributorName	Γεωργίλα, Χριστίνα	el
heal.contributorName	Τσικκίνης, Αννίβας	el
heal.contributorName	Βασίλαρου, Ντόροθυ - Σταματία	el
heal.contributorName	Μινάκη, Πλουμίτσα	el
heal.contributorName	Σφήκας, Κωνσταντίνος	el
heal.contributorName	Σπανός, Ευάγγελος	el
heal.contributorName	Τριχόπουλος, Δημήτριος	el
heal.identifier.secondary	DOI: 10.1093/annonc/mdt207
heal.language	en
heal.access	campus
heal.publicationDate	2013
heal.bibliographicCitation	Lagiou, P., Samoli, E., Lagiou, A., Zourna, P., Barbouni, A. et al. (2013) A comparison of hormonal profiles between breast cancer and benign breast disease: A case-control study. "Annals of Oncology", 24 (10), p.2527-2533	en
heal.abstract	Benign breast disease (BBD), particularly proliferative BBD, is an established breast cancer risk factor. However, there has been no systematic attempt to compare the hormonal profiles of the two conditions. In a case-control investigation in Athens, Greece, we compared levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1), as well as their principal binding proteins, between breast cancer patients, women with BBD by histological type (proliferative and nonproliferative) and women with no breast pathology. Patients and methods: We studied 466 women with incident breast cancer, 704 women with BBD and 244 healthy women. We used multiple regression to compare log-transformed serum hormone levels of breast cancer patients with those of healthy women and women with BBD by histological type (proliferative and nonproliferative BBD). Results: The hormonal profile of breast cancer in our study was in line with the generally accepted hormonal profile of this disease, as reported from large cohort studies. Compared with healthy women, breast cancer patients tended to have higher levels of steroid hormones. The evidence was strong for estrone (difference 21.5%, P < 0.001), weaker for testosterone (difference 15.8%, P = 0.07) and weaker still for estradiol (difference 12.0%, P = 0.18). Also compared with healthy women, breast cancer patients had barely higher levels of IGF-1 (difference 2.0%, P = 0.51), but had significantly lower levels of IGF binding protein 3 (IGFBP-3) (difference -6.7%, P = 0.001). Compared with women with BBD, breast cancer patients had nonstatistically significantly lower levels of steroid hormones, but they had higher levels of IGF-1 [difference 5.5%, 95% confidence interval (CI) 0.7% to 10.6%] and lower levels of IGFBP-3 (difference -3.7%, 95% CI -6.7% to -0.7%). Differences were more pronounced when breast cancer patients were contrasted to women with proliferative BBD. Conclusions: Our findings suggest that high levels of IGF-1 may be an important factor toward the evolution of BBD to breast cancer.	en
heal.journalName	Annals of Oncology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true