A novel easy-to-use phantom for the determination of MTF in SPECT scanners

dc.contributor.author	Φούντος, Γεώργιος Π.	el
dc.contributor.author	Μιχαήλ, Χρήστος Μ.	el
dc.contributor.author	Ζανγκλής, Αντώνιος	el
dc.contributor.author	Σαμαρτζής, Αλέξανδρος Π.	el
dc.contributor.author	Μαρτήνη, Ν.	el
dc.date.accessioned	2015-06-06T17:37:53Z
dc.date.available	2015-06-06T17:37:53Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15351
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://scitation.aip.org/content/aapm/journal/medphys	en
dc.subject	Film
dc.subject	Flood source
dc.subject	LSF
dc.subject	MTF
dc.subject	PSF
dc.subject	SPECT
dc.subject	Ακτινογραφικό φιλμ
dc.subject	Πηγή πλημμυρών
dc.title	A novel easy-to-use phantom for the determination of MTF in SPECT scanners	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Technology
heal.classification	Ιατρική
heal.classification	Τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/10470-6
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Τεχνολογία
heal.contributorName	Κούκου, Β.	el
heal.contributorName	Καλατζής, Ιωάννης	el
heal.contributorName	Κανδαράκης, Ιωάννης Σ.	el
heal.identifier.secondary	DOI: http://dx.doi.org/10.1118/1.3688196
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2012-03
heal.bibliographicCitation	Fountos, G., Michail, C., Zanglis, A., Samartzis, A., Marini, N., et al. (2012) A novel easy-to-use phantom for the determination of MTF in SPECT scanners. "Medical Physics", 39 (3), p. 1561-1570. Available from: http://scitation.aip.org/content/aapm/journal/medphys/39/3/10.1118/1.3688196 [Accessed: 06/06/2015].	en
heal.abstract	Purpose: To evaluate modulation transfer function (MTF) in single photon emission computed tomography (SPECT) systems using the line spread function (LSF) method and a novel flood source which can be easily fabricated with materials accessible in hospital facilities. Methods: A Tc-99m-based flood source (Eγ 140 keV) consisting of a radiopharmaceutical bound to the grains of a radiographic film was prepared in laboratory. Various films and radiopharmaceuticals were examined, in order to obtain a thin homogenous and reproducible flood source. The source showing best uniformity and reproducibility was placed between two PMMA blocks and images were obtained by using the brain tomographic acquisition protocol (brain) and the myocardial perfusion tomographic acquisition protocol (heart). MTF was evaluated by determining the LSF for various reconstruction methods and filters. MTF calculation was obtained by the utilization of a custom made software in which a method similar to the one proposed by Boone Med. Phys. 28, 356-360 (2001) was implemented. All imaging experiments were performed in a Siemens e-Cam γ-camera. Furthermore, MTF was assessed through the point spread function (PSF) following conventional methods. Results: The optimum homogeneity was obtained by immersing an Agfa MammoRay HDR Medical x-ray film in a solution of dithiothreitol (DTT, 10-3 M)/Tc-99m(III)-DMSA (DMSA: trivalent technetium-99m-dimercapto-succinic acid, 40 mCi/40 ml) for 30 min in the dark. These films exhibited better uniformity (CV <1.9). Higher MTF values were obtained for the brain scan protocol with iterative 3D with eight iterations reconstruction method. MTF of the brain protocol was in all cases better than the heart protocol. MTFs derived from LSF were more precise compared with those obtained from PSF since their reproducibility was better in all cases, providing a mean standard deviation of 0.0065, in contrary to the PSF method which gave 0.0348. Conclusions: The method presented here is novel and easy to implement, requiring materials commonly found in clinical practice. Furthermore, this technique which is based on the LSF method reduces measurement noise levels due to the larger amount of data averaging than in the conventional PSF method. Furthermore, MTF can be assessed easily, in three dimensions (3D), by placing the flood source either in sagittal or coronal direction.	en
heal.publisher	Williamson, Jeffrey F.	en
heal.journalName	Medical Physics	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true