Botulinum toxin and anal fissure

dc.contributor.author	Γιαννακοπούλου, Ελένη	el
dc.date.accessioned	2015-06-06T17:49:43Z
dc.date.available	2015-06-06T17:49:43Z
dc.date.issued	2015-06-06
dc.identifier.uri	http://hdl.handle.net/11400/15353
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://link.springer.com/journal/384	en
dc.subject	Anal fissure
dc.subject	Botulinum toxin
dc.subject	Chemical sphincterotomy
dc.subject	Efficacy
dc.subject	Lateral internal sphincterotomy
dc.subject	Safety
dc.subject	Πρωκτική σχισμή
dc.subject	Αλλαντική τοξίνη
dc.subject	Χημική σφιγκτηροτομή
dc.subject	Αποτελεσματικότητα
dc.subject	Πλευρική εσωτερική σφιγκτηροτομή
dc.subject	Ασφάλεια
dc.title	Botulinum toxin and anal fissure	en
heal.type	journalArticle
heal.secondaryTitle	efficacy and safety systematic review	en
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Παθολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85016075
heal.identifier.secondary	DOI: 10.1007/s00384-011-1286-5
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2012-01
heal.bibliographicCitation	Yiannakopoulou, E. (2012) Botulinum toxin and anal fissure: efficacy and safety systematic review. "International Journal of Colorectal Disease", 27 (1), p. 1-9. Available from: http://link.springer.com/article/10.1007%2Fs00384-011-1286-5 [Accessed: 06/06/2015].	en
heal.abstract	Purpose: The main Purpose: of this study was to investigate the efficacy and safety of botulinum toxin in the treatment of anal fissure. An answer was attempted to the following research questions: (i) what is the efficacy of botulinum toxin in healing of anal fissure compared to placebo, (ii) what is the efficacy of botulinum toxin in healing of anal fissure compared to other means of chemical sphincterotomy, (iii) what is the efficacy of botulinum toxin in healing of anal fissure compared to surgical sphincterotomy, (iv) what is the short term safety of botulinum toxin injections and (v) what is the long term safety of botulinum toxin injections. Methods: Clinical trials investigating the effect of botulinum toxin in the treatment of anal fissure met inclusion criteria. Case reports and case series were also included for the estimation of safety. Meta-analysis was not performed due to clinical heterogeneity. Results: The comparator could be placebo, nitroglycerin ointment, or lateral internal sphincterotomy, with dosage ranging from 20 IU to 50 IU of botulinum toxin. Fissure healing was the most commonly reported primary endpoint but the time period from botulinum toxin injection to fissure healing ranged from 2 weeks to 4 months. Accordingly, outcome data were also heterogenous. Conclusions: Botulinum toxin injections should be considered a minimally invasive therapeutic option for the treatment of chronic anal fissure. However, well designed randomized trials are needed for the valid estimation of the efficacy and safety of botulinum toxin in this therapeutic indication.	en
heal.publisher	Buhr, Heinz-Johannes	en
heal.journalName	International Journal of Colorectal Disease	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true