Determination of nicotine and cotinine in meconium from Greek neonates and correlation with birth weight and gestational age at birth

dc.contributor.author	Τσινισιζέλη, Νικολέτα	el
dc.contributor.author	Σωτηρούδης, Γεώργιος	el
dc.contributor.author	Ξενάκης, Αριστοτέλης	el
dc.contributor.author	Λυκερίδου - Αβραμιώτη, Κατερίνα	el
dc.date.accessioned	2015-06-07T06:29:29Z
dc.date.available	2015-06-07T06:29:29Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15385
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S0045653514011801	en
dc.subject	Meconium
dc.subject	Tobacco
dc.subject	Μηκώνιο
dc.subject	Καπνός
dc.title	Determination of nicotine and cotinine in meconium from Greek neonates and correlation with birth weight and gestational age at birth	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Midwifery
heal.classification	Ιατρική
heal.classification	Μαιευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh96006072
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Μαιευτική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85082793
heal.identifier.secondary	doi:10.1016/j.chemosphere.2014.09.094
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Μαιευτικής.	el
heal.publicationDate	2015-01
heal.bibliographicCitation	Tsinisizeli, N., Sotiroudis, G., Xenakis, A. and Lykeridou-Avramioti, K. (January 2015). Determination of nicotine and cotinine in meconium from Greek neonates and correlation with birth weight and gestational age at birth. Chemosphere. 119. pp. 1200-1207. Elsevier Ltd: 2015. Available from: http://www.sciencedirect.com/science/article/pii/S0045653514011801 [Accessed 01/11/2014]	el
heal.abstract	Tobacco exposure during pregnancy is a major factor of morbidity and mortality for both the pregnant woman and the fetus. Several studies in the past have detected and quantified tobacco smoke biomarkers in infant meconium samples. Aim of this study was to measure prenatal exposure to tobacco smoke by detecting nicotine and cotinine in meconium and to try to evaluate the extent of exposure to smoke through passive smoking as well as the relationship between tobacco biomarker meconium concentrations and neonatal outcomes. Tobacco smoke biomarkers nicotine and cotinine were detected and quantitated in meconium from tobacco exposed and non-exposed Greek neonates using liquid chromatography–tandem mass spectrometry. The study included 45 neonates from active, passive and non-smoking women during pregnancy. The results showed significant values of nicotine and cotinine concentration in neonates from both active and passive smokers which reached 125 ng g−1 for nicotine and 98.5 ng g−1 for cotinine and varied according to the type and level of exposure. In general nicotine and cotinine concentrations correlated with the degree of active smoking by the mother. Similarly, nicotine and cotinine were measured in the meconium of infants of passive smokers at concentrations comparable to those of infants whose mothers were moderate smokers. Our findings show that exposure of the fetus to tobacco biomarkers can be substantial even in passive maternal smoking and there is a statistically significant negative correlation between nicotine or cotinine concentrations in meconium and birth weight or gestational age at birth.	en
heal.publisher	Elsevier Ltd	en
heal.journalName	Chemosphere	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true