Bone calcium/phosphorus ratio determination using dual energy X-ray method

dc.contributor.author	Σωτηροπούλου, Παναγιώτα Ι.	el
dc.contributor.author	Φούντος, Γεώργιος Κ.	el
dc.contributor.author	Μαρτίνη, Νίκη Δ.	el
dc.contributor.author	Κούκου, Βάϊα Ν.	el
dc.contributor.author	Μιχαήλ, Χρήστος Μ.	el
dc.date.accessioned	2015-06-07T10:05:46Z
dc.date.available	2015-06-07T10:05:46Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15441
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S1120179715000356	en
dc.subject	Bone
dc.subject	Hydroxyapatite
dc.subject	Οστό
dc.subject	Υδροξυαπατίτη
dc.title	Bone calcium/phosphorus ratio determination using dual energy X-ray method	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Biomedical engineering
heal.classification	Ιατρική
heal.classification	Βιοϊατρική τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85014237
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Βιοϊατρική τεχνολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85063508
heal.contributorName	Κανδαράκης, Ιωάννης Σ.	el
heal.contributorName	Νικηφορίδης, Γεώργιος Σ.	el
heal.identifier.secondary	doi:10.1016/j.ejmp.2015.01.019
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2015-05
heal.bibliographicCitation	Sotiropoulou, P., Fountos, G., Martini, N., Koukou, V., Michail, C., et al. (May 2015). Bone calcium/phosphorus ratio determination using dual energy X-ray method. Physica Medica. 31(3). pp. 307-313. Elsevier B.V: 2015. Available from: http://www.sciencedirect.com/science/article/pii/S1120179715000356 [Accessed 25/02/2015]	en
heal.abstract	Non-invasive dual energy methods have been used extensively on osteoporosis diagnosis estimating parameters, such as, Bone Mineral Density (BMD) and Bone Mineral Content (BMC). In this study, an X-ray dual energy method (XRDE) was developed for the estimation of the bone Calcium-to-Phosphorous (Ca/P) mass ratio, as a bone quality index. The optimized irradiation parameters were assessed by performing analytical model simulations. X-ray tube output, filter material and thickness were used as input parameters. A single exposure technique, combined with K-edge filtering, was applied. The optimal X-ray spectra were selected according to the resulted precision and accuracy values. Experimental evaluation was performed on an XRDE system incorporating a Cadmium Telluride (CdTe) photon counting detector and three bone phantoms with different nominal mass Ca/P ratios. Additionally, the phantoms’ mass Ca/P ratios were validated with energy-dispersive X-ray spectroscopy (EDX). Simulation results showed that the optimum filter atomic number (Z) ranges between 57 and 70. The optimum spectrum was obtained at 100 kVp, filtered with Cerium (Ce), with a surface density of 0.88 g/cm2. All Ca/P ratio measurements were found to be accurate to within 1.6% of the nominal values, while the precision ranged between 0.91 and 1.37%. The accuracy and precision values of the proposed non-invasive method contributes to the assessment of the bone quality state through the mass Ca/P ratio determination.	en
heal.publisher	Elsevier B.V.	en
heal.journalName	Physica Medica	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true