Does the setup of Monte Carlo simulations influence the calculated properties and effect of gold nanoparticles in radiation therapy?

dc.contributor.author	Σπύρου, Σπυρίδων Β.	el
dc.contributor.author	Μακρής, Δημήτριος	el
dc.contributor.author	Λούντος, Γεώργιος	el
dc.date.accessioned	2015-06-07T10:14:17Z
dc.date.available	2015-06-07T10:14:17Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15444
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S1120179715001180	en
dc.subject	Monte Carlo
dc.subject	Gold nanoparticles
dc.subject	Μόντε Κάρλο
dc.subject	Χρυσά νανοσωματίδια
dc.title	Does the setup of Monte Carlo simulations influence the calculated properties and effect of gold nanoparticles in radiation therapy?	en
heal.type	report
heal.classification	Medicine
heal.classification	Biomedical engineering
heal.classification	Ιατρική
heal.classification	Βιοϊατρική τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85014237
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Βιοϊατρική τεχνολογία
heal.identifier.secondary	doi:10.1016/j.ejmp.2015.05.008
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2015
heal.abstract	Purpose To investigate whether the dose-scoring process of Monte Carlo (MC) simulations of Gold nanoparticles (GNPs) in radiation therapy affects the results. Methods The GATE MC toolkit was used to simulate the irradiation of a water phantom containing a single solid or hollow GNP with 250 kVp and 6 MV photons. The dose was scored in 20 nm × 20 nm × 50 μm, 100 nm × 100 nm × 50 μm and 200 nm × 200 nm × 50 μm volumes using dose-scoring voxels of size 1 nm × 1 nm × 50 μm, 10 nm × 10 nm × 50 μm, 50 nm × 50 nm × 50 μm and 100 nm × 100 nm × 50 μm Εxcess dose depth-dose (EDDD) curves and lateral beam profiles were used to compare the dose-scoring voxels. Results In a given volume, neither the EDDD curves nor the lateral beam profiles are affected by the size of the dose-scoring voxels, subject to noise and uncertainty. Certain features of the EDDD curves are clearly seen in larger volumes, but hidden within the uncertainty and noise levels in smaller volumes. For the lateral beam profiles, it is the larger volumes that result in misleading results and the smaller ones that give the expected results. However, the limited statistics result in asymmetries and skewness in the profiles. Conclusion For a given volume, the dose curves are not affected by the size of the dose-scoring voxels. However, the voxel size may hide or reveal the finer structure of the dose curves and/or may result in misleading curves.	en
heal.publisher	Elsevier B.V.	en
heal.fullTextAvailability	true