Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of post-operative wound infection

dc.contributor.author	Γιαννακοπούλου, Ελένη	el
dc.date.accessioned	2015-06-07T16:02:43Z
dc.date.available	2015-06-07T16:02:43Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15481
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://jac.oxfordjournals.org/	en
dc.subject	Antibacterial agents
dc.subject	Antibiotic Prophylaxis
dc.subject	biomedical research
dc.subject	Humans
dc.subject	Surgical Wound Infection
dc.subject	Treatment Outcome
dc.subject	Αντιβακτηριακοί παράγοντες
dc.subject	Αντιβιωτική προφύλαξη
dc.subject	Βιοιατρική έρευνα
dc.subject	Άνθρωποι
dc.subject	Μόλυνση πληγής από το χειρουργείο
dc.title	Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of post-operative wound infection	en
heal.type	journalArticle
heal.secondaryTitle	systematic review	en
heal.classification	Medicine
heal.classification	Pharmacology
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85005635
heal.keywordURI	http://lod.nal.usda.gov/17342
heal.identifier.secondary	DOI: 10.1093/jac/dkp030
heal.language	en
heal.access	campus
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2009
heal.bibliographicCitation	Yiannakopoulou, E. (2009) Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of post-operative wound infection: systematic review. "Journal of Antimicrobial Chemotherapy", 63 (4), p. 843-845. Available from: http://jac.oxfordjournals.org/content/63/4/843 [Accessed: 07/06/2015].	en
heal.abstract	Sir, The effectiveness of antibiotic prophylaxis in low-risk patients remains a matter of investigation, since it is well known that antibiotic prophylaxis can be associated with adverse drug events1 (e.g. haemolytic anaemia after proper administration of just one dose of cephalosporin prophylaxis2). Randomized controlled trials (RCTs) are widely accepted to be the most reliable method for determining the efficacy of an intervention; however, methodological limitations have been expressed in terms of safety assessment.3 The aim of this systematic review was to describe the methodology of safety evaluation in RCTs concerning antibiotic prophylaxis in hernia and breast surgeries and in laparoscopic cholecystectomy (LC). PubMed, Scopus, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Reviews of Effects, Science Citation Index Expanded and Google Scholar were searched in order to identify articles assessing the effectiveness of systemic antibiotic prophylaxis versus placebo in hernia surgery, breast surgery and LC. An electronic search was performed from 1995 … [introduction]	en
heal.publisher	Donnelly, J. P.	en
heal.journalName	Journal of Antimicrobial Chemotherapy	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true