Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents

dc.contributor.author	Γιαννακοπούλου, Ευγενία	el
dc.date.accessioned	2015-06-07T16:04:22Z
dc.date.available	2015-06-07T16:04:22Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15482
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://link.springer.com	en
dc.subject	Antiplatelet activity
dc.subject	Anti-inflammatory agents
dc.subject	Αντιαιμοπεταλιακή δράση
dc.subject	Αντι-φλεγμονώδεις παράγοντες
dc.title	Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents	en
heal.type	journalArticle
heal.secondaryTitle	clinical implications	en
heal.classification	Aesthetics
heal.classification	Cosmetics
heal.classification	Αισθητική
heal.classification	Κοσμητολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85033139
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Κοσμητολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85005615
heal.identifier.secondary	DOI: 10.1007/s00228-013-1477-9
heal.language	en
heal.access	campus
heal.publicationDate	2013
heal.bibliographicCitation	Yiannakopoulou, E. (2013) Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents: Clinical implications. "European Journal of Clinical Pharmacology", 69 (7), p.1369-1373	en
heal.abstract	Pharmacogenomics investigates interindividual genetic variability in the DNA sequence of drug targets, drug-metabolizing enzymes or disease genes, RNA expression, or protein translation of genes affecting drug response and drug safety. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications with well-documented variation in patient response in terms of efficacy and safety. This variation may in part be explained by pharmacogenomics. Methods: In this paper I review data on the pharmacogenomics of aspirin and other NSAIDs focusing on clinical implications. Results: Existing scientific evidence supports the pharmacogenomic basis of interindividual variation in treatment response to aspirin and NSAIDs, with clinical implications for antiplatelet action, cancer chemoprevention, and drug safety. However, further research efforts are needed before knowledge on the pharmacogenomics of aspirin and NSAIDs can be implemented in clinical practice. Conclusion: The outcome of these research efforts would be anticipated to have added value for both science and society, contributing to the enhanced efficacy and safety of these agents through patient selection.	en
heal.publisher	Springer	en
heal.journalName	European Journal of Clinical Pharmacology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true