The hormonal profile of benign breast disease

dc.contributor.author	Σαμόλη, Ευαγγελία	el
dc.contributor.author	Τριχόπουλος, Δημήτριος	el
dc.contributor.author	Λάγιου, Αρετή	el
dc.contributor.author	Ζουρνά, Παντελίνα	el
dc.contributor.author	Γεωργιλά, Χριστίνα	el
dc.date.accessioned	2015-06-07T20:23:51Z
dc.date.available	2015-06-07T20:23:51Z
dc.date.issued	2015-06-07
dc.identifier.uri	http://hdl.handle.net/11400/15548
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.nature.com	en
dc.subject	Benign breast disease
dc.subject	Estrogens
dc.subject	Testosterone
dc.subject	Καλοήθεις παθήσεις του μαστού
dc.subject	Οιστρογόνα
dc.subject	Τεστοστερόνη
dc.title	The hormonal profile of benign breast disease	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85134159
heal.contributorName	Μινάκη, Πλουμίτσα	el
heal.contributorName	Μπαρμπούνη, Αναστασία	el
heal.contributorName	Βασίλαρου, Ντόροθυ - Σταματία	el
heal.contributorName	Τσικκίνης, Αννίβας	el
heal.contributorName	Σφήκας, Κωνσταντίνος	el
heal.contributorName	Σπανός, Ευάγγελος	el
heal.contributorName	Λάγιου, Παγώνα	el
heal.identifier.secondary	DOI: 10.1038/bjc.2012.493
heal.language	en
heal.access	campus
heal.publicationDate	2013
heal.bibliographicCitation	Samoli, E., Trichopoulos, D., Lagiou, A., Zourna, P., Georgila, C. et al. (2013) The hormonal profile of benign breast disease. "British Journal of Cancer", 108 (1), p.199-204	en
heal.abstract	Limited information exists about the endocrine milieu of benign breast disease (BBD), a documented breast cancer risk factor. We compared blood levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1) between BBD patients by histological type and women without breast pathology.Methods:We studied 578 BBD patients and 178 healthy women in Athens, Greece, who provided blood samples, and completed interviewer-administered questionnaires.Results:Of the BBD patients, 254 had non-proliferative disease, 268 proliferative disease without atypia and 56 atypical hyperplasia. Comparing BBD patients with healthy women, the per cent differences (and 95% confidence intervals) for blood hormones, among pre-menopausal and peri/post-menopausal women, respectively, were: 22.4% (-4.0%, 56.1%) and 32.0% (5.6%, 65.1%) for estradiol; 26.2% (10.1%, 44.8%) and 30.9% (16.8%, 46.6%) for estrone; 19.5% (3.1%, 38.4%) and 16.5% (-5.0%, 42.9%) for testosterone; and-5.2% (-13.8%, 4.4%) and-12.1% (-19.8%,-3.6%) for IGF-1. Steroid hormones tended to be higher in proliferative compared with non-proliferative BBD.Conclusions:Circulating steroid hormones tend to be higher among women with BBD than women with no breast pathology and higher in proliferative than non-proliferative disease; these patterns are more evident among peri/post-menopausal women. In peri/post-menopausal women IGF-1 was lower among women with BBD compared with healthy women.	en
heal.journalName	British Journal of Cancer	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true