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dc.contributor.author Σαμόλη, Ευαγγελία el
dc.contributor.author Τριχόπουλος, Δημήτριος el
dc.contributor.author Λάγιου, Αρετή el
dc.contributor.author Ζουρνά, Παντελίνα el
dc.contributor.author Γεωργιλά, Χριστίνα el
dc.date.accessioned 2015-06-07T20:23:51Z
dc.date.available 2015-06-07T20:23:51Z
dc.date.issued 2015-06-07
dc.identifier.uri http://hdl.handle.net/11400/15548
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://www.nature.com en
dc.subject Benign breast disease
dc.subject Estrogens
dc.subject Testosterone
dc.subject Καλοήθεις παθήσεις του μαστού
dc.subject Οιστρογόνα
dc.subject Τεστοστερόνη
dc.title The hormonal profile of benign breast disease en
heal.type journalArticle
heal.classification Medicine
heal.classification Oncology
heal.classification Ιατρική
heal.classification Ογκολογία
heal.classificationURI http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI **N/A**-Ιατρική
heal.classificationURI **N/A**-Ογκολογία
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85134159
heal.contributorName Μινάκη, Πλουμίτσα el
heal.contributorName Μπαρμπούνη, Αναστασία el
heal.contributorName Βασίλαρου, Ντόροθυ - Σταματία el
heal.contributorName Τσικκίνης, Αννίβας el
heal.contributorName Σφήκας, Κωνσταντίνος el
heal.contributorName Σπανός, Ευάγγελος el
heal.contributorName Λάγιου, Παγώνα el
heal.identifier.secondary DOI: 10.1038/bjc.2012.493
heal.language en
heal.access campus
heal.publicationDate 2013
heal.bibliographicCitation Samoli, E., Trichopoulos, D., Lagiou, A., Zourna, P., Georgila, C. et al. (2013) The hormonal profile of benign breast disease. "British Journal of Cancer", 108 (1), p.199-204 en
heal.abstract Limited information exists about the endocrine milieu of benign breast disease (BBD), a documented breast cancer risk factor. We compared blood levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1) between BBD patients by histological type and women without breast pathology.Methods:We studied 578 BBD patients and 178 healthy women in Athens, Greece, who provided blood samples, and completed interviewer-administered questionnaires.Results:Of the BBD patients, 254 had non-proliferative disease, 268 proliferative disease without atypia and 56 atypical hyperplasia. Comparing BBD patients with healthy women, the per cent differences (and 95% confidence intervals) for blood hormones, among pre-menopausal and peri/post-menopausal women, respectively, were: 22.4% (-4.0%, 56.1%) and 32.0% (5.6%, 65.1%) for estradiol; 26.2% (10.1%, 44.8%) and 30.9% (16.8%, 46.6%) for estrone; 19.5% (3.1%, 38.4%) and 16.5% (-5.0%, 42.9%) for testosterone; and-5.2% (-13.8%, 4.4%) and-12.1% (-19.8%,-3.6%) for IGF-1. Steroid hormones tended to be higher in proliferative compared with non-proliferative BBD.Conclusions:Circulating steroid hormones tend to be higher among women with BBD than women with no breast pathology and higher in proliferative than non-proliferative disease; these patterns are more evident among peri/post-menopausal women. In peri/post-menopausal women IGF-1 was lower among women with BBD compared with healthy women. en
heal.journalName British Journal of Cancer en
heal.journalType peer-reviewed
heal.fullTextAvailability true


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες