Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals

dc.contributor.author	Giglio, Javier	en
dc.contributor.author	Πάτσης, Γεώργιος Π.	el
dc.contributor.author	Πιρμέττης, Ιωάννης Χ.	el
dc.contributor.author	Παπαδόπουλος, Μηνάς Σ.	el
dc.contributor.author	Ραφτοπούλου, Αικατερίνη Π.	el
dc.date.accessioned	2015-06-09T17:19:49Z
dc.date.available	2015-06-09T17:19:49Z
dc.date.issued	2015-06-09
dc.identifier.uri	http://hdl.handle.net/11400/15607
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.elsevier.com/	en
dc.subject	Bioreductive compounds
dc.subject	Hypoxia imaging
dc.subject	Rhenium
dc.subject	Technetium
dc.subject	Tricarbonyl complexes
dc.subject	Βιοαναγωγικές ενώσεις
dc.subject	Ρήνειο
dc.subject	Τεχνήτιο
dc.subject	Τρικαρβονυλικά συμπλέγματα
dc.title	Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals	en
heal.type	journalArticle
heal.secondaryTitle	in vitro and in vivo studies	en
heal.classification	Technology
heal.classification	Chemical technology
heal.classification	Τεχνολογία
heal.classification	Χημική τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85133147
heal.classificationURI	http://skos.um.es/unescothes/C00565
heal.classificationURI	N/A-Τεχνολογία
heal.classificationURI	N/A-Χημική τεχνολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85133086
heal.contributorName	Πελεκάνου, Μαρία	el
heal.contributorName	León, Elsa T.	en
heal.contributorName	González, Mercedes Belén	en
heal.contributorName	Cerecetto, Hugo Eduardo	en
heal.contributorName	Rey, Ana M.	en
heal.identifier.secondary	DOI: 10.1016/j.ejmech.2007.05.015
heal.language	en
heal.access	campus
heal.publicationDate	2008-04
heal.bibliographicCitation	GIGLIO. J., PATSIS, G.P., PIRMETTIS, I.C., PAPADOPOULOS, M.S., RAFTOPOULOU, A.P., et al. (2008). Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals: in vitro and in vivo studies. European Journal of Medicinal Chemistry. [online] 43 (4). p. 741-748. Available from: http://www.elsevier.com/[Accessed 07/06/2007]	en
heal.abstract	The synthesis of a ligand containing a nitrobenzyl group as bioreductive pharmacophore and the preparation of the corresponding technetium and rhenium complexes are presented. 99mTc labelling was performed in high yield (>90%) by ligand substitution using fac-[99mTc(CO)3(H2O)3]+ as precursor. The structure of the technetium complex was established by chromatographic comparison with the analogous rhenium compound which was fully characterized by elemental analysis, spectroscopic methods and X-ray crystallography. Reduction potential of the rhenium complex was in the characteristic range for bioreductive compounds. Biodistribution in normal mice was characterized by fast blood and soft tissue depuration and combined excretion via the hepatobiliary and urinary systems. Tumour uptake was low, probably due to low lipophilicity but tumour/muscle ratios were favourable as a consequence of high excretion.	en
heal.publisher	Elsevier	en
heal.journalName	European Journal of Medicinal Chemistry	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true