Ester-modified 99mTcO[SN(R)S/S] mixed ligand complexes

dc.contributor.author	Τσουκαλάς, Χαράλαμπος	el
dc.contributor.author	Πιρμέττης, Ιωάννης Χ.	el
dc.contributor.author	Πάτσης, Γεώργιος Π.	el
dc.contributor.author	Παπαδόπουλος, Απόστολος	el
dc.contributor.author	Ραφτοπούλου, Αικατερίνη Π.	el
dc.date.accessioned	2015-06-09T17:48:49Z
dc.date.available	2015-06-09T17:48:49Z
dc.date.issued	2015-06-09
dc.identifier.uri	http://hdl.handle.net/11400/15609
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.elsevier.com/	en
dc.subject	Brain--Imaging
dc.subject	Mixed ligand complexes
dc.subject	Rhenium
dc.subject	Technetium
dc.subject	απεικόνιση εγκεφάλου
dc.subject	Ρήνειο
dc.subject	τεχνήτιο
dc.title	Ester-modified 99mTcO[SN(R)S/S] mixed ligand complexes	en
heal.type	journalArticle
heal.secondaryTitle	synthesis and preliminary evaluation	en
heal.classification	Technology
heal.classification	Chemical technology
heal.classification	Medicine
heal.classification	Τεχνολογία
heal.classification	Χημική τεχνολογία
heal.classification	Ιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85133147
heal.classificationURI	http://skos.um.es/unescothes/C00565
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Τεχνολογία
heal.classificationURI	N/A-Χημική τεχνολογία
heal.classificationURI	N/A-Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2008117487
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85133086
heal.contributorName	Τερζής, Αριστείδης	el
heal.contributorName	Παπαδόπουλος, Μηνάς Σ.	el
heal.contributorName	Χιωτέλλης, Ευστράτιος	el
heal.identifier.secondary	DOI: 10.1016/S0969-8051(01)00249-9
heal.language	en
heal.access	campus
heal.publicationDate	2001
heal.bibliographicCitation	TSOUKALAS, C., PIRMETTIS, I.C., PATSIS, G.P., PAPADOPOULOS, A., RAFTOPOULOU, A.P., et al. (2001). Ester-modified 99mTcO[SN(R)S/S] mixed ligand complexes: synthesis and preliminary evaluation. Nuclear Medicine and Biology. [online] 28 (8). p. 975-982. Available from: http://www.elsevier.com/[Accessed 09/11/2001]	en
heal.abstract	Two novel 99mTc-(SNS/S) complexes: a mono-ester compound carrying an ethyl ester group on the tridentate ligand, 99mTcO[C2H5OOCCH2N(CH 2CH2S)2][SC6H4CH 3], 3, and a diester compound, carrying a second ethyl ester group on the monodentate ligand, 99mTcO[C2H5OOCCH2N(CH 2CH2S)2][SC6H4COOC 2H5], 4, were synthesized. The corresponding oxorhenium(V) complexes, 1 and 2 were also synthesized. Enzymatic hydrolysis demonstrated that 3 remains intact after 10 min incubation while 4 is totally converted to an unidentified hydrophilic complex. Tissue distribution data in mice revealed that both complexes, 3 and 4, exhibit significant initial brain uptake (1.42 and 1.01% of injected dose at 5 minutes post injection respectively) and fast blood clearance.	en
heal.publisher	Elsevier	en
heal.journalName	Nuclear Medicine and Biology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true