Aspirin and NSAIDs for breast cancer chemoprevention

dc.contributor.author	Γιαννακοπούλου, Ευγενία	el
dc.date.accessioned	2015-06-09T20:35:02Z
dc.date.available	2015-06-09T20:35:02Z
dc.date.issued	2015-06-09
dc.identifier.uri	http://hdl.handle.net/11400/15618
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://ovidsp.tx.ovid.com/sp-3.15.1b/ovidweb.cgi?WebLinkFrameset=1&S=EBMNFPCLBCDDIIKBNCKKKDJCIIGBAA00&returnUrl=ovidweb.cgi%3fMain%2bSearch%2bPage%3d1%26S%3dEBMNFPCLBCDDIIKBNCKKKDJCIIGBAA00&directlink=http%3a%2f%2fgraphics.tx.ovid.com%2fovftpdfs%2fFPDDNCJCKDKBBC00%2ffs047%2fovft%2flive%2fgv024%2f00008469%2f00008469-900000000-99549.pdf&filename=Aspirin+and+NSAIDs+for+breast+cancer+chemoprevention.&navigation_links=NavLinks.S.sh.22.1&link_from=S.sh.22%7c1&pdf_key=FPDDNCJCKDKBBC00&pdf_index=/fs047/ovft/live/gv024/00008469/00008469-900000000-99549&D=ovft&link_set=S.sh.22\|1\|sl_10\|resultSet\|S.sh.22.23\|0	en
dc.subject	καρκίνος του μαστού
dc.subject	χημειοπροφύλαξη
dc.subject	κυκλοοξυγενάσεις
dc.subject	ασπιρίνη
dc.subject	θρομβοξάνη
dc.subject	breast cancer
dc.subject	Chemoprevention
dc.subject	Cyclooxygenases
dc.subject	Aspirin
dc.subject	thromboxane
dc.title	Aspirin and NSAIDs for breast cancer chemoprevention	en
heal.type	journalArticle
heal.classification	Φαρμακευτική
heal.classification	Καρκίνος
heal.classification	Pharmacy
heal.classification	Cancer
heal.classificationURI	N/A-Φαρμακευτική
heal.classificationURI	N/A-Καρκίνος
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	http://zbw.eu/stw/descriptor/18899-3
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh92002504
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh96008414
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85008731
heal.identifier.secondary	DOI: 10.1097/CEJ.0000000000000098
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	en
heal.publicationDate	2014-11-06
heal.bibliographicCitation	Yiannakopoulou, E.C. (2014) Aspirin and NSAIDs for breast cancer chemoprevention. European Journal of Cancer Prevention. [Online] Available from: http://ovidsp.tx.ovid.com [Accessed 09/06/2015]	en
heal.abstract	Novel treatment strategies are needed for breast cancer chemoprevention. Tamoxifen is the only drug approved for the chemoprevention of estrogen receptor-positive breast cancer. However, to date, no treatment exists for the chemoprevention of estrogen receptor-negative breast cancer. NSAID use is associated with a reduced risk of breast cancer. However, the biological mechanisms underlying the effect of NSAID on breast cancer are not well defined. NSAIDs inhibit cyclooxygenases, thus preventing the formation of prostaglandins, prostacyclin, and thromboxane. NSAIDs also exert other biological effects, including generation of reactive oxygen species and inhibition of nuclear factor-κB-mediated signals. This review synthesizes the evidence on the COX-2-independent mechanisms of action of aspirin, salicylates, and other NSAIDs on breast cancer.	en
heal.publisher	Lippincott Williams and Wilkins	en
heal.journalName	European Journal of Cancer Prevention	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true