In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

dc.contributor.author	Baldi, Giovanni	en
dc.contributor.author	Ravagli, Costanza	en
dc.contributor.author	Mazzantini, Filippo	en
dc.contributor.author	Λούντος, Γεώργιος	el
dc.contributor.author	Adán, Jaume	en
dc.date.accessioned	2015-06-10T13:48:04Z
dc.date.available	2015-06-10T13:48:04Z
dc.date.issued	2015-06-10
dc.identifier.uri	http://hdl.handle.net/11400/15638
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.dovepress.com/in-vivo-anticancer-evaluation-of-the-hyperthermic-efficacy-of-anti-hum-peer-reviewed-fulltext-article-IJN	en
dc.subject	Υπερθερμία
dc.subject	Απεικόνιση
dc.subject	Μαγνητικά νανοσωματίδια
dc.subject	Πολυμερικοί νανοφορείς
dc.subject	Υπολογιστική τομογραφία εκπομπής μονήρους φωτονίου
dc.subject	μελάνωμα
dc.subject	Hyperthermia
dc.subject	Imaging
dc.subject	Magnetic nanoparticles
dc.subject	Polymeric nanocarriers
dc.subject	Single-photon emission computed tomography
dc.subject	Skin cancer
dc.title	In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles	en
heal.type	journalArticle
heal.classification	Ιατρική
heal.classification	Καρκίνος
heal.classification	Medicine
heal.classification	Cancer
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Καρκίνος
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/18899-3
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2006001159
heal.contributorName	Masa, Marc	en
heal.contributorName	Ψιμάδας, Δημήτριος	el
heal.contributorName	Φραγκογιώργη, Ειρήνη Α.	el
heal.contributorName	Locatelli, Erica	en
heal.contributorName	Innocenti, Claudia	en
heal.contributorName	Sangregorio, Claudio	en
heal.contributorName	Comes Franchini, Mauro Comes	en
heal.identifier.secondary	DOI: 10.2147/IJN.S61273
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2014-06-24
heal.bibliographicCitation	Baldi, G., Ravagli, C., Mazzantini, F., Loudos, G., Adan, J. et al. (2014) n vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles. International Journal of Nanomedicine. [Online] 9 (1), pp.3037-3047. Available from: http://www.dovepress.com [Accessed 10/06/2015]	en
heal.abstract	Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma.	en
heal.publisher	Dove Medical Press Ltd.	en
heal.journalName	International Journal of Nanomedicine	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true