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dc.contributor.author Baldi, Giovanni en
dc.contributor.author Ravagli, Costanza en
dc.contributor.author Mazzantini, Filippo en
dc.contributor.author Λούντος, Γεώργιος el
dc.contributor.author Adán, Jaume en
dc.date.accessioned 2015-06-10T13:48:04Z
dc.date.available 2015-06-10T13:48:04Z
dc.date.issued 2015-06-10
dc.identifier.uri http://hdl.handle.net/11400/15638
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://www.dovepress.com/in-vivo-anticancer-evaluation-of-the-hyperthermic-efficacy-of-anti-hum-peer-reviewed-fulltext-article-IJN en
dc.subject Υπερθερμία
dc.subject Απεικόνιση
dc.subject Μαγνητικά νανοσωματίδια
dc.subject Πολυμερικοί νανοφορείς
dc.subject Υπολογιστική τομογραφία εκπομπής μονήρους φωτονίου
dc.subject μελάνωμα
dc.subject Hyperthermia
dc.subject Imaging
dc.subject Magnetic nanoparticles
dc.subject Polymeric nanocarriers
dc.subject Single-photon emission computed tomography
dc.subject Skin cancer
dc.title In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles en
heal.type journalArticle
heal.classification Ιατρική
heal.classification Καρκίνος
heal.classification Medicine
heal.classification Cancer
heal.classificationURI **N/A**-Ιατρική
heal.classificationURI **N/A**-Καρκίνος
heal.classificationURI http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI http://zbw.eu/stw/descriptor/18899-3
heal.keywordURI http://id.loc.gov/authorities/subjects/sh2006001159
heal.contributorName Masa, Marc en
heal.contributorName Ψιμάδας, Δημήτριος el
heal.contributorName Φραγκογιώργη, Ειρήνη Α. el
heal.contributorName Locatelli, Erica en
heal.contributorName Innocenti, Claudia en
heal.contributorName Sangregorio, Claudio en
heal.contributorName Comes Franchini, Mauro Comes en
heal.identifier.secondary DOI: 10.2147/IJN.S61273
heal.language en
heal.access campus
heal.recordProvider Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε. el
heal.publicationDate 2014-06-24
heal.bibliographicCitation Baldi, G., Ravagli, C., Mazzantini, F., Loudos, G., Adan, J. et al. (2014) n vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles. International Journal of Nanomedicine. [Online] 9 (1), pp.3037-3047. Available from: http://www.dovepress.com [Accessed 10/06/2015] en
heal.abstract Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. en
heal.publisher Dove Medical Press Ltd. en
heal.journalName International Journal of Nanomedicine en
heal.journalType peer-reviewed
heal.fullTextAvailability true


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες