Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides

dc.contributor.author	Βενέτικου, Μαρία	el
dc.contributor.author	Μελέαγρος, Λουκάς	el
dc.contributor.author	Ghatei, Mohammad	en
dc.contributor.author	Bloom, Stephen	en
dc.date.accessioned	2015-06-11T00:49:19Z
dc.date.issued	2015-06-11
dc.identifier.uri	http://hdl.handle.net/11400/15675
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.spandidos-publications.com	en
dc.subject	Ηπατική νόσος
dc.title	Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Nursing (http://skos.um.es/unescothes/C02778)
heal.classification	Ιατρική
heal.classification	Νοσηλευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02778
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Νοσηλευτική
heal.identifier.secondary	OI: 10.3892/ol.2013.1384
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.publicationDate	2013
heal.bibliographicCitation	Venetikou, M., Meleagros, L., Ghatei, M. and Bloom, S. (2013) Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides. "Oncology Letters", 6 (2), p.499-506	en
heal.abstract	7B2, a protein initially isolated from the porcine pituitary gland, has been identified in numerous animal and human tissues, with the highest concentrations in the pituitary and hypothalamus. The 7B2 molecule is highly evolutionarily conserved and is considered to be indispensable in the function and regulation of proprotein convertase 2 (PC2). In the present study, the plasma 7B2 immunoreactivity (7B2-IR) of 18 patients with liver disease was studied. Of these patients, seven (three male and four female), aged 37-67 [54.6±13.5 (SD)] years, suffered from liver cirrhosis of cryptogenic (n=2) or alcoholic (n=5) aetiology. The remaining 11 patients (four male and seven female), aged 22-76 [56.1±17.6 (SD)] years, suffered from miscellaneous liver abnormalities. The clinical diagnosis was confirmed in the majority of patients by the histological examination of a percutaneous liver biopsy or by appropriate radiological investigations. Plasma bilirubin, alkaline phosphatase, aspartate aminotransferase, albumin, prothrombin time, electrolytes, urea and creatinine were measured. The plasma 7B2-IR levels were estimated using a sensitive radioimmunoassay (RIA), and the elution position of 7B2-IR was verified by gel chromatography. The mean plasma 7B2-IR concentration in patients with liver disease was 99.44±15.9 pmol/l. In the patients with hepatocellular damage due to metastatic tumours [Ca bronchus, carcinoid (n=6)], the 7B2-IR concentrations were significantly higher [185±36.9 pmol/l, (P<0.05)] compared with the overall subjects with liver damage. The results of the present study demonstrate that 7B2-IR is increased in liver disease, with the highest levels detected in patients with tumourous liver conditions.	en
heal.journalName	Oncology Letters	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false