Multiple organ dysfunction syndrome (MODS)

dc.contributor.author	Παπαθανασόγλου, Ελισάβετ Δ.	el
dc.contributor.author	Γιαννακοπούλου, Μαργαρίτα	el
dc.contributor.author	Μποζάς, Ευάγγελος	el
dc.contributor.author	Μπότη, Σοφία	el
dc.contributor.author	Κλετσίου, Ελένη	el
dc.date.accessioned	2015-01-08T19:44:40Z
dc.date.available	2015-01-08T19:44:40Z
dc.date.issued	2015-01-08
dc.identifier.uri	http://hdl.handle.net/11400/3582
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Multiple organ failure
dc.subject	Σύνδρομο δυσλειτουργίας πολλαπλών οργάνων
dc.subject	επίπεδα ορμονών
dc.subject	επιβίωση
dc.subject	πόνος
dc.subject	dysfunction syndrome
dc.subject	stress hormone levels
dc.subject	pain
dc.title	Multiple organ dysfunction syndrome (MODS)	en
heal.type	journalArticle
heal.secondaryTitle	A state of decreased stress hormone levels and association with survival and pain	en
heal.classification	Ιατρική
heal.classification	Νοσηλευτική
heal.classification	Medicine
heal.classification	Nursing
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Νοσηλευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85093362
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh89005207
heal.contributorName	Ταμβάκη, Ελένη	el
heal.contributorName	Πατέλη, Ιωάννα	el
heal.contributorName	Καραμπίνης, Ανδρέας	el
heal.contributorName	Φούκα, Γεωργία	el
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2011
heal.bibliographicCitation	Papathanassoglou, E., Giannakopoulou, M., Bozas, E., Mpoti, S., Kletsiou, E. et al. (2011). Multiple organ dysfunction syndrome (MODS): a state of decreased stress hormone levels and association with survival and pain. “The World of Critical Care Nursing”. 8(2)	el
heal.abstract	AIM: Critically ill patients experience high levels of stress. The pathophysiologic sequence of stress in MODS and cellular effects of stress neuropeptides have not been studied. This research explored: a) serum levels of ACTH, cortisol, prolactin, neuropeptide Y (NPY) and substance P (SP) in critically ill subjects and controls, b) potential association between levels of those stress neuropeptides, survival and pain. METHODS: Prospective correlational study with repeated measures. Fifty-three critically ill patients with diverse primary diagnoses and 53 -age and gender-matched healthy controls were studied. NPY and SP were quantified by ELISA and ACTH, cortisol and prolactin by cheluminense immunoassays. Pain levels were assessed by Payen and Puntillo scales. Clinical severity was quantified by MOF and MODS. RESULTS: a) statistically significant differences between critically ill and control subjects in regard with cortisol (p< 0.0001), NPY (p< 0.0001) and SP (p< 0.05) levels, b) statistically significant associations between ACTH and pain intensity levels assessed by Payen (r=0.391, p=0.018) and Puntillo (r=0.509, p=0.002). NPY levels were significantly lower in patients receiving analgesia (p=0.042), c) lower ACTH and cortisol levels in survivors (p< 0.05) d) at the day of least severity, a significant association between SP levels and MOF was observed (r=0.29, p< 0.05). CONCLUSION: a) Despite the fact that NPY and SP are stress neuropeptides, their levels appear to be decreased in MODS patients, b) the observed association between stress neuropeptide levels and survival in critical illness needs to be explored further, c) bedside measurement of selected neuropeptides in the future may provide an estimation of pain in uncommunicative patients. REFERENCE(S). 1. Papathanassoglou ED et al. Multiple organ dysfunction syndrome pathogenesis and care: a complex systems' theory perspective. Nursing in Critical Care, 13(5):249-59, 2008	en
heal.publisher	European federation of Critical Care Nursing associations	en
heal.journalName	The World of Critical Care Nursing	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true