Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy

dc.contributor.author	Παπαδογιαννάκης, Εμμανουήλ Ι.	el
dc.contributor.author	Ανδρίτσος, Γεώργιος Δ.	el
dc.contributor.author	Κοντός, Βασίλειος Ι.	el
dc.contributor.author	Σπανάκος, Γρηγόρης	el
dc.contributor.author	Κουτής, Χαρίλαος	el
dc.date.accessioned	2015-01-09T13:02:16Z
dc.date.available	2015-01-09T13:02:16Z
dc.date.issued	2015-01-09
dc.identifier.uri	http://hdl.handle.net/11400/3621
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/	en
dc.subject	Canine
dc.subject	allopurinol
dc.subject	Σκύλος
dc.subject	Αλλοπουρινόλη
dc.subject	CD4+ T cells
dc.subject	CD8+ T cells
dc.title	Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy	en
heal.type	journalArticle
heal.classification	Veterinary pathophysiology
heal.classification	Ιατρική
heal.classification	Κτηνιατρική
heal.classification	Ιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2003001354
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Κτηνιατρική
heal.classificationURI	N/A-Ιατρική
heal.keywordURI	http://lod.nal.usda.gov/6718
heal.contributorName	Βελονάκης, Εμμανουήλ Ν.	el
heal.identifier.secondary	DOI:10.1016/j.tvjl.2009.08.001
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας.Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Yγιεινής).	el
heal.publicationDate	2009-08
heal.bibliographicCitation	Papadogiannakis, E., Andritsos, G., Kontos, V., Spanakos, G., Koutis, H., et al. (2010). Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy. "The Veterinary Journal". 186 (2), pp.262-263.	en
heal.abstract	Canine leishmaniosis (CL) is a common systemic parasitic disease that is endemic in many Mediterranean countries including Greece. The immune reaction to the parasite is critical to the outcome of the infection and the response to treatment. Some studies have shown a reduction of circulating CD4+ T cells and of the CD4+/CD8+ ratio in dogs with CL and these changes normalised following treatment with meglumine antimoniate or amphotericin B. Allopurinol is used as a monotherapy for the chronic treatment of CL. The aim of the present study was to determine the circulating CD4+ and CD8+ T lymphocyte numbers and the CD4+/CD8+ ratio in 19 dogs diagnosed with CL before and after prolonged allopurinol monotherapy (18 months). A significant decrease in circulating CD4+ T cells was observed in dogs with CL before treatment. Prolonged allopurinol monotherapy improved the number of circulating CD4+ T cells, but did not restore their number to within the normal range.	en
heal.publisher	ScienceDirect	en
heal.journalName	The Veterinary Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true