Aim of this work was to study the reduction of volume of the extremity after Combined Decongestive Treatment (CDT) twice a day for four weeks. CDT includes skin care, mid, bandage, exercises and education of the patient. Method. We treated 71 patients with either primary or secondary lymphedema (PL-SL) for four weeks Results. From 71 patients with lymphedema 20 patients had primary lymphedema (pl)and 51 secondary lymphedema (si). 48 were females (13 pi - 35 si) and 23 males (7pl - 16 si). At the first measurement we found a mean Edema = 3025 ml, which was 46% over than the normal level of lymph. At the last measurement we found a mean Edema = 1099 ml, which was 14% over than the normal level of lymph. In all patients we had a mean reduction of volume of 65,09% in upper extremity lymphedemas and a mean reduction of volume of 69,96% of the lower extremity. In patients with lymphedema <12 months the reduction was about 72,5% whereas in patients with lymphedema <12 months the reduction was about 55,5%. Conclusion. The treatment of Lymphedema with CDT was successfully in all patients with almost the same results in both extremities Prevention of the onset of lymphedema is of extreme importance. However, a return to as normal a lifestyle as possible by the patient is also essential. The earlier treatment begins after the onset of lymphedema, the better the prognosis for the patient. Moreover the target of the treatment must be a reduction of the volume between 50%-70% of the initial oedema.