Study on the Prevention of Allergy in Children in Europe (SPACE): Allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth

dc.contributor.author	Halmerbauer, Gerhard	en
dc.contributor.author	Gartner, Christian	en
dc.contributor.author	Schierl, Michael	en
dc.contributor.author	Arshad, Hassan	en
dc.contributor.author	Dean, Tara	en
dc.date.accessioned	2015-01-09T22:35:58Z
dc.date.available	2015-01-09T22:35:58Z
dc.date.issued	2015-01-10
dc.identifier.uri	http://hdl.handle.net/11400/3682
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Newborn infants
dc.subject	dust mites
dc.subject	Allergy in children
dc.subject	Βρέφη
dc.subject	Ακάρεα σκόνης
dc.subject	Πρόληψη
dc.subject	Prevention
dc.subject	Αλλεργία στα παιδιά
dc.title	Study on the Prevention of Allergy in Children in Europe (SPACE): Allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth	en
heal.type	journalArticle
heal.generalDescription	And the SPACE collaborative study team	en
heal.classification	Medicine
heal.classification	Allergy
heal.classification	Ιατρική
heal.classification	Αλλεργία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85003662
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Αλλεργία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85066048
heal.keywordURI	http://lod.nal.usda.gov/32479
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85099138
heal.contributorName	Koller, Dieter Y.	en
heal.contributorName	Karmaus, Wilfried	en
heal.contributorName	Kuehr, Joachim	en
heal.contributorName	Forster, Johannes	en
heal.contributorName	Urbanek, Radvan	en
heal.contributorName	Frischer, Thomas	en
heal.identifier.secondary	DOI: 10.1034/j.1399-3038.13.s.15.11.x
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας.Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Yγιεινής).	el
heal.publicationDate	2002
heal.bibliographicCitation	Halmerbauer, G., Gartner, C., Schierl, M., Arshad, H., Dean, T., et al. (2002). Study on the Prevention of Allergy in Children in Europe (SPACE): Allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth."Pediatric allergy and immunology". Vol 13 (15): pp.47-54.	en
heal.abstract	Several studies have demonstrated that early intervention may modulate the natural course of atopic disease. Our objective was to prevent sensitization to house-dust mite and food allergens, as well as the development of atopic symptoms during infancy, by the combination of an educational package and the use of mite allergen-impermeable mattress encasings. A multicentre European, population-based, randomized, controlled study of children at increased atopic risk [Study on the Prevention of Allergy in Children in Europe (SPACE)] was performed in five countries (Austria, Germany, Greece, the UK, and Lithuania), and included three cohorts – schoolchildren, toddlers, and newborns. We report on the newborn cohort. A total of 696 newborns were included from Austria, the UK, and Germany. Inclusion criteria were: a positive history of parental allergy; and a positive skin-prick test or specific immunoglobulin E (IgE) (IgE 1.43 kU/L) against at least one out of a panel of common aeroallergens in one or both parents. At 1 year of age, the overall sensitization rate against the tested allergens [dust-mite allergens: Dermatophagoides pteronyssinus and Dermatophagoides farinae (Der p and Der f)] and food allergens (egg, milk) in the prophylactic group was 6.21% vs. 10.67% in the control group. The prevalence of sensitization against Der p was 1.86% in the prophylactic group vs. 5% in the control group. In conclusion, we were able to demonstrate, in a group of newborns at risk for atopic diseases, that the sensitization rate to a panel of aero- and food allergens could be effectively decreased through the use of impermeable mattress encasings and the implementation of easy-to-perform preventive measures.	en
heal.publisher	Blackwell Munksgaard	en
heal.journalName	Pediatric allergy and immunology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true