Eosinophil-derived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life

dc.contributor.author	Frischer, Thomas	en
dc.contributor.author	Halmerbauer, Gerhard	en
dc.contributor.author	Gartner, Christian	en
dc.contributor.author	Rath, R.	en
dc.contributor.author	Tauber, E.	en
dc.date.accessioned	2015-01-10T00:16:41Z
dc.date.available	2015-01-10T00:16:41Z
dc.date.issued	2015-01-10
dc.identifier.uri	http://hdl.handle.net/11400/3685
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	neonates
dc.subject	Ηωσινοφιλική φλεγμονή
dc.subject	Ρινικό έκκριμα
dc.subject	Νεογέννητα
dc.subject	Eosinophilic inflammation
dc.subject	nasal lavage
dc.title	Eosinophil-derived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life	en
heal.type	journalArticle
heal.generalDescription	and the collaborative SPACE team	en
heal.generalDescription	Short communication	en
heal.classification	Medicine
heal.classification	Allergy
heal.classification	Ιατρική
heal.classification	Αλλεργία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85003662
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Αλλεργία
heal.keywordURI	http://lod.nal.usda.gov/32902
heal.contributorName	Schierl, Michael	en
heal.contributorName	Koller, Dieter Y.	en
heal.contributorName	Urbanek, Radvan	en
heal.contributorName	Forster, Johannes	en
heal.contributorName	Kuehr, Joachim	en
heal.identifier.secondary	DOI: 10.1034/j.1398-9995.2000.00773.x
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας.Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Yγιεινής).	el
heal.publicationDate	2003-10
heal.bibliographicCitation	Frischer, T., Halmerbauer, G., Gartner, C., Rath, R., Tauber, E., et al. (2003). Eosinophil-derived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life. "Allergy". Vol 55 (8), pp.773-777 (el)	en
heal.abstract	Background: Eosinophilic airways inflammation forms the pathophysiologic basis for a proportion of children at risk of developing recurrent wheezing. Early preventive measures and/or anti-inflammatory treatment may be guided by the identification of such children. Methods: We studied upper-airways inflammation by nasal lavage in a cohort of 397 infants within the first 4 weeks of life. They participated in an international multicenter study on the prevention of allergy in Europe (SPACE-Biomed II Program). A volume of 2 ml of prewarmed 0.9% saline was instilled into each nasal cavity and immediately re-collected by a suction device. The average recovery was 502 ml (SD: 311 ml). The concentrations of eosinophil cationic protein (ECP) and eosinophil protein X (EPX) were determined by RIA analysis. Results: ECP was detectable (>2 mg/l) in 47% of samples (173/365) and EPX (>3 mg/l) in 54.7% (197/360). Children with a doctor's diagnosis of a wheezy bronchitis within the first 6 months of life (n=40) had significantly higher ECP and EPX concentrations in the nasal lavage at 4 weeks of age (median ECP: 14 mg/l; 5-95th percentile: 0-122.4 mg/l) than children without such diagnosis (median ECP: 0 mg/l; 5±95th percentile: 0-86.6 mg/l; P<0.05). Corresponding figures for EPX were 12.14 mg/l (0-148.98 mg/l) vs 7.5 mg/l (0-81.46 mg/l; P<0.05). No associations between nasal ECP/EPX and the development of food allergy or eczema were observed. Conclusions: Increased nasal ECP and EPX in the first 4 weeks of life are associated with wheezing in 6-month-old infants at increased risk of atopic disease. We suggest that this might be related to a general tendency for a Th2 cytokine pattern in these young infants and subsequent trafficking of eosinophils into the nasal mucosa, or it might be a consequence of intrauterine allergen exposure.	en
heal.journalName	Allergy	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true