Eosinophil cationic protein and eosinophil protein X in the nasal lavage of children during the first 4 weeks of life

dc.contributor.author	Halmerbauer, Gerhard	en
dc.contributor.author	Gartner, Christian	en
dc.contributor.author	Koller, Dieter Y.	el
dc.contributor.author	Schierl, Michael	en
dc.contributor.author	Kuehr, Joachim	en
dc.date.accessioned	2015-01-10T00:52:14Z
dc.date.available	2015-01-10T00:52:14Z
dc.date.issued	2015-01-10
dc.identifier.uri	http://hdl.handle.net/11400/3686
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	neonates
dc.subject	Allergy in children
dc.subject	Allergy in infants
dc.subject	Ηωσινοφιλική κατιονική πρωτεΐνη
dc.subject	Ηωσινοφιλική πρωτεΐνη Χ
dc.subject	Νεογέννητα
dc.subject	Eosinophil cationic protein
dc.subject	Eosinophil protein X
dc.subject	Αλλεργίες στα βρέφη
dc.title	Eosinophil cationic protein and eosinophil protein X in the nasal lavage of children during the first 4 weeks of life	en
heal.type	journalArticle
heal.generalDescription	And the SPACE Collaborative Study Team	en
heal.classification	Medicine
heal.classification	Allergy
heal.classification	Ιατρική
heal.classification	Αλλεργία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85003662
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Αλλεργία
heal.keywordURI	http://lod.nal.usda.gov/32902
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85099138
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh92005487
heal.contributorName	Forster, Johannes	en
heal.contributorName	Urbanek, Radvan	en
heal.contributorName	Frischer, Thomas	en
heal.identifier.secondary	DOI: 10.1034/j.1398-9995.2000.00439.x
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας.Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Yγιεινής).	el
heal.publicationDate	2001-12
heal.bibliographicCitation	Halmerbauer, G., Gartner, C., Koller, D., Schierl, Μ., Kuehr, J., et al. (2001). Eosinophil cationic protein and eosinophil protein X in the nasal lavage of children during the first 4 weeks of life. "Allergy". Vol 55: pp.1121-1126.	en
heal.abstract	Eosinophil cationic protein (ECP) and eosinophil protein X (EPX) are well established as markers of eosinophil activation. We analyzed ECP and EPX concentrations in nasal lavage fluids (NALF) of 378 neonates during their first 4 weeks of life. Inclusion criteria were a positive history of parental allergy and a positive skin prick test or specific IgE (RAST class i2) against at least one out of a panel of common aeroallergens in one or both parents. Twentyfour infants with no history of parental allergy were used as controls. A volume of 2 ml of 0.9% saline was instilled into each nostril and immediately recovered by a suction device. ECP and EPX were analyzed by radioimmunoassay. In 65 samples of three consecutive lavages, EPX was detected in nine samples (13.8%) in the control group, whereas it was detected in 197/360 samples (54.7%) in the study population. The corresponding figures for ECP were 17/65 (26.2%) in the control group and 173/365 (47.4%) in the study group. Both proteins showed a skewed distribution (median/5-95th percentiles for ECP: 0 mg/l [0-69.4] and EPX: 6.6 mg/l [0-73.2]). The differences between the control group and the study group were statistically significant, regardless of the allergic disease of the parents. In children of allergic parents, activation proteins of the eosinophil granulocyte are released on the nasal mucosal surface in about 50% of the studied population at the age of 4 weeks. This early onset of eosinophil activation in the nasal respiratory epithelium may reflect a genetic predisposition to allergy or early exposure to allergens.	en
heal.journalName	Allergy	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true