Evaluation of recalcification of bone metastases after radiotherapy and I.V. infusion of disodium pamidronate, using image processing techniques. Comparative assessment using measurements of the optical density of plain radiography

dc.contributor.author	Κουλουλίας, Βασίλειος	el
dc.contributor.author	Αντύπας, Χρήστος	el
dc.contributor.author	Δαρδούφας, Κωνσταντίνος	el
dc.contributor.author	Κούβαρης, Ιωάννης	el
dc.contributor.author	Σάνδηλος, Παναγιώτης	el
dc.date.accessioned	2015-01-14T10:02:08Z
dc.date.issued	2015-01-14
dc.identifier.uri	http://hdl.handle.net/11400/3998
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Image processing
dc.subject	Optical densitometry
dc.subject	Επεξεργασία εικόνας
dc.subject	Οπτική πυκνομετρία
dc.title	Evaluation of recalcification of bone metastases after radiotherapy and I.V. infusion of disodium pamidronate, using image processing techniques. Comparative assessment using measurements of the optical density of plain radiography	en
heal.type	report
heal.generalDescription	Physica Medica - Vol. XVII, N. 1, January-March 2001	en
heal.classification	Medicine
heal.classification	Medical technology
heal.classification	Ιατρική
heal.classification	Ιατρικά όργανα και εξοπλισμός
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02465
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ιατρικά όργανα και εξοπλισμός
heal.contributorName	Σεφερλής, Σταύρος	el
heal.contributorName	Ματσόπουλος, Γεώργιος Κ.	el
heal.contributorName	Ουζούνογλου, Νικόλαος Κ.	el
heal.contributorName	Ασβεστάς, Παντελής Α.	el
heal.contributorName	Βλάχος, Λουκάς	el
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2001
heal.abstract	The aim of the study was to radiographically monitor the early effect of radiotherapy in conjunction with Disodium Pamidronate (DP), on metastatic bone disease, using image-processing techniques. Eight patients with bone lytic metastasis received radiotherapy with a 6MV linac up to a dose of 30Gy (3Gy per fraction, 5 days a week) combined with 6 monthly sessions of infusional 180mgr of DP. Conventional X-rays of all patients were obtained at every session of the treatment, retaining the same settings for each exposure. Quality assurance of accuracy and precision of X-ray exposure parameters showed acceptable values. The analysis of the image attributes was based on measuring the first order statistics of the gray level histogram such as mean value (MVGLH) and energy (EGLH), in 24 small rectangular areas constituting the region of lytic metastasis. The measurements showed a 35.72 % reduction of EGLH and a 3.17% increase of MVGLH, before and after the combined treatment. Further analysis concerning the measurement of the optical density of the film in the region of lytic metastases at every session of the treatment revealed a reduction up to 29.12% (P < 0.001, Kruskal-Wallis test). The changes in the MVGLH were high correlated with the changes of EGLH in terms of Rs = 0.98 (P < 0.0001, spearman’s-rho test) and furthermore with the changes in optical density in terms of Rs = 0.87 (P < 0.0001, spearman’s-rho test). These findings indicate a significant level of reliability for both of the above-mentioned methods and beyond this, an important objective early increase in bone mass and formation, which was difficult to be identified visually by the experts.	en
heal.publisher	[χ.ό.]	el
heal.fullTextAvailability	true