Impaired P600 in neuroleptic naive patients
with first-episode schizophrenia

dc.contributor.author	Παπαγεωργίου, Χαράλαμπος	el
dc.contributor.author	Κονταξάκης, Βασίλειος Π.	el
dc.contributor.author	Χαβάκη-Κονταξάκη, Μπεάτα Ι.	el
dc.contributor.author	Σταμούλη, Σοφία	el
dc.contributor.author	Βάσιος, Χρήστος	el
dc.date.accessioned	2015-01-14T11:07:44Z
dc.date.issued	2015-01-14
dc.identifier.uri	http://hdl.handle.net/11400/4016
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	First-episode schizophrenia
dc.subject	Short-term memory
dc.subject	Πρώτο επεισόδιο σχιζοφρένειας
dc.subject	Εργασία μνήμης
dc.title	Impaired P600 in neuroleptic naive patients with first-episode schizophrenia	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Psychiatry
heal.classification	Ιατρική
heal.classification	Ψυχιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C03187
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ψυχιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85121972
heal.contributorName	Ασβεστάς, Παντελής Α.	el
heal.contributorName	Ματσόπουλος, Γεώργιος Κ.	el
heal.contributorName	Κοντοπαντελής, Ευάγγελος	el
heal.contributorName	Ραμπαβίλας, Ανδρέας Δ.	el
heal.contributorName	Ουζούνογλου, Νικόλαος Κ.	el
heal.contributorName	Χριστοδούλου, Γεώργιος Ν.	el
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2001
heal.bibliographicCitation	Papageorgiou, C., Kontaxakis, V., Kontaxaki-Havaki, B., Stamouli, S. and Vasios, C. (September 2001). Impaired P600 in neuroleptic naive patients with ®rst-episode schizophrenia. Neuroreport: Cognitive Neuroscience And Neuropsychology. 12(13). pp. 2801-2806. Lippincott Williams & Wilkins, Inc	en
heal.abstract	Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 elicited during a WM test in drug-naive first-episode schizophrenics (FES) compared to healthy controls. We examined 16 drug-naive first-episode schizophrenic patients and 23 healthy controls matched for age and sex. Compared with controls schizophrenic patients showed reduced P600 amplitude on left temporoparietal region and increased P600 amplitude on left occipital region. With regard to the latency, the patients exhibited significantly prolongation on right temporoparietal region. The obtained pattern of differences classified correctly 89.20% of patients. Memory performance of patients was also significantly impaired relative to controls. Our results suggest that second-pass parsing process of information processing, as indexed by P600, elicited during a WM test, is impaired in FES. Moreover, these findings lend support to the view that the auditory WM in schizophrenia involves or affects a circuitry including temporoparietal and occipital brain areas.	en
heal.publisher	Lippincott Williams & Wilkins, Inc	en
heal.journalName	Neuroreport: Cognitive Neuroscience And Neuropsychology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true