Liver fat, visceral adiposity, and sleep disturbances contribute to the
development of insulin resistance and glucose intolerance in nondiabetic dialysis patients

dc.contributor.author	Σακκάς, Γεώργιος Κ.	el
dc.contributor.author	Καρατζαφέρη, Χριστίνα	el
dc.contributor.author	Ζιντζαράς, Ηλίας	el
dc.contributor.author	Γιαννάκη, Χριστόφορος Δ.	el
dc.contributor.author	Λιακόπουλος, Βασίλειος	el
dc.date.accessioned	2015-01-15T22:24:46Z
dc.date.available	2015-01-15T22:24:46Z
dc.date.issued	2015-01-16
dc.identifier.uri	http://hdl.handle.net/11400/4111
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.the-aps.org/	en
dc.subject	Λειτουργική ικανότητα
dc.subject	Ευαισθησία στην ινσουλίνη γλυκόζης από το στόμα
dc.subject	Ποιότητα ζωής
dc.subject	Δείκτης ελέγχου ποσοτική ινσουλίνη ευαισθησία
dc.subject	Functional capacity
dc.subject	Oral glucose insulin sensitivity
dc.subject	Quality of life
dc.subject	Quantitative insulin-sensitivity check index
dc.title	Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients	en
heal.type	journalArticle
heal.generalDescription	CALL FOR PAPERS Insulin Resistance and the Cardiometabolic Syndrome: Adipose Tissue and Skeletal Muscle Factors	en
heal.classification	Medicine
heal.classification	Nutrition
heal.classification	Ιατρική
heal.classification	Διατροφή
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02780
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Διατροφή
heal.contributorName	Λαβδάς, Ελευθέριος	el
heal.contributorName	Νταμανή, Ελένη	el
heal.contributorName	Λιάκος, Νίκος	el
heal.contributorName	Κουτεντάκης, Γιάννης	el
heal.contributorName	Στεφανίδης, Ιωάννης	el
heal.contributorName	Φεζουλίδης, Ιωάννης Β.	el
heal.identifier.secondary	DOI:10.1152/ajpregu.00935.2007
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Ραδιολογίας και Ακτινολογίας.	el
heal.publicationDate	2008-12
heal.bibliographicCitation	Sakkas, G. K., Karatzaferi, C., Zintzaras, E., Giannaki, C. D., Liakopoulos, V., et al. (2008). Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients." American Journal of Physiology - Regulatory, Integrative and Comparative Physiology" 295 (6), p.1721-1729.	en
heal.abstract	Hemodialysis patients exhibit insulin resistance (IR) in target organs such as liver, muscles, and adipose tissue. The aim of this study was to identify contributors to IR and to develop a model for predicting glucose intolerance in nondiabetic hemodialysis patients. After a 2-h, 75-g oral glucose tolerance test (OGTT), 34 hemodialysis patients were divided into groups with normal (NGT) and impaired glucose tolerance (IGT). Indices of insulin sensitivity were derived from OGTT data. Measurements included liver and muscle fat infiltration and central adiposity by computed tomography scans, body composition by dual energy X-ray absorptiometer, sleep quality by full polysomnography, and functional capacity and quality of life (QoL) by a battery of exercise tests and questionnaires. Cut-off points, as well as sensitivity and specificity calculations were based on IR (insulin sensitivity index by Matsuda) using a receiver operator characteristics (ROC) curve analysis. Fifteen patients were assigned to the IGT, and 19 subjects to the NGT group. Intrahepatic fat content and visceral adiposity were significantly higher in the IGT group. IR indices strongly correlated with sleep disturbances, visceral adiposity, functional capacity, and QoL. Visceral adiposity, O2 desaturation during sleep, intrahepatic fat content, and QoL score fitted into the model for predicting glucose intolerance. A ROC curve analysis identified an intrahepatic fat content of >3.97% (sensitivity, 100; specificity, 35.7) as the best cutoff point for predicting IR. Visceral and intrahepatic fat content, as well as QoL and sleep seemed to be involved at some point in the development of glucose intolerance in hemodialysis patients. Means of reducing fat depots in the liver and splachnic area might prove promising in combating IR and cardiovascular risk in hemodialysis patients	en
heal.publisher	American Physiological Society	en
heal.journalName	AJP - Regulatory, Integrative and Comparative Physiology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true