Haemodialysis patients with sleep apnoea syndrome experience
increased central adiposity and altered muscular composition
and functionality

dc.contributor.author	Σακκάς, Γεώργιος Κ.	el
dc.contributor.author	Γουργουλιάνης, Κωνσταντίνος Ι.	el
dc.contributor.author	Καρατζαφέρη, Χριστίνα	el
dc.contributor.author	Λιακόπουλος, Βασίλειος	el
dc.contributor.author	Μαριδάκη, Μαρία	el
dc.date.accessioned	2015-01-15T22:53:23Z
dc.date.available	2015-01-15T22:53:23Z
dc.date.issued	2015-01-16
dc.identifier.uri	http://hdl.handle.net/11400/4113
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Αιμοκάθαρση
dc.subject	Άλιπης μάζα σώματος
dc.subject	Μυϊκή λειτουργική ικανότητα
dc.subject	Αποφρακτική άπνοια ύπνου σύνδρομο - υποπνοιών
dc.subject	Σπλαχνικός λιπώδης ιστός
dc.subject	Haemodialysis
dc.subject	Lean body mass (LBM)
dc.subject	Muscle functional capacity
dc.subject	Obstructive sleep apnoea–hypopnoea syndrome
dc.subject	Visceral adipose tissue
dc.title	Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Sleep
heal.classification	Ιατρική
heal.classification	Ύπνος
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85123396
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ύπνος
heal.contributorName	Παστάκα, Χάϊδω Γ.	el
heal.contributorName	Λαβδάς, Ελευθέριος	el
heal.contributorName	Soher, Brian J.	el
heal.contributorName	Ντόβας, Σπύρος	el
heal.contributorName	Φεζουλίδης, Ιωάννης Β.	el
heal.contributorName	Χατζηγεωργίου, Γεώργιος Μ.	el
heal.contributorName	Στεφανίδης, Ιωάννης	el
heal.identifier.secondary	DOI:10.1093/ndt/gfm559
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Ραδιολογίας και Ακτινολογίας.	el
heal.publicationDate	2007-09
heal.bibliographicCitation	Sakkas, G. K., Gourgoulianis, K, I., Karatzaferi, C., Liakopoulos, V., Maridaki, M. D., et al. (2008). Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality. "Nephrology Dialysis Transplantation". 28 (1), p.336-344.	en
heal.abstract	ackground. Sleep apnoea frequently affects patients with end-stage renal disease. However, it is still unclear whether or to what extent sleep disorders may affect functional capacity and quality of life in haemodialysis patients. We tested the hypothesis that apneic dialysis patients due to the lack of restorative sleep will have a further reduced functional capacity and further compromised quality of life compared to their nonapneic counterparts. Methods. Forty-three clinically stable haemodialysis patients (13 F, 56.6_19.4 years) were examined. After polysomnographic analysis, patients were divided in two groups according to their calculated apnoea hypopnoea index (AHI; cutoff 5). Primary outcomes were intergroup differences in the following: (1) physical capacity and muscle performance, assessed by functional tests, (2) quality of life, assessed by the SF-36, (3) body composition, measured by DEXA and (4) muscle composition and size, as well as (5) visceral (VAT) and subcutaneous (SAT) adipose tissue, calculated by computed tomography. Results. Twenty-two patients had AHI >5 (4F,AHI¼28.8_22.3). The adjusted analysis for age,BMI and years in dialysis therapy, showed that the low-AHI group (N¼21, 9 F, AHI¼1.8_1.3) had better functional capacity, and performed better in muscle strength and endurance tests compared to the high-AHI group. There were no differences in lean body mass and % total body fat between groups, however, values for VAT, VAT/TAT ratio and thigh muscles’ fat infiltration were increased in the high-AHI group. VAT correlated with BMI (r¼0.682,P¼0.001), functional capacity (r¼0.558, P¼0.001) apnoea hypopnoea index (r¼0.530, P¼0.001). There were no statistical significant differences in quality of life between the two groups. To further account for age and BMI differences, a subgroup of patients was matched by age, sex and BMI (N¼10/group). In the matched analysis, all the above statistical differences remained, between the low-AHI and high-AHI groups. Conclusions. Haemodialysis patients with sleep apnoea syndrome demonstrate poorer functional capacity, physical performance and muscle composition, compared to non-apneic dialysis patients. Overall, sleep apnoea appears to partly contribute to the total diminished functional capacity of haemodialysis patients.	en
heal.journalName	Nephrology Dialysis Transplantation	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true